OBJECTIVE Plasma hemopexin activity, associated with increased vascular permeability, was evaluated in healthy pregnant and non-pregnant women and in pre-eclamptic women. METHODS Hemopexin activity and the hemopexin inhibitor, extracellular ATP, were assayed in plasma from pregnant (n = 10), preeclamptic (n = 9), and non-pregnant women (n = 10) using standard methods. Abdominal fascia tissue ...

Serum concentrations of VEGF (Vascular Endothelial Growth Factor) are elevated in preeclampsia. In addition to inducing mitosis and increase permeability of endothelial cells, VEGF was reported to activate endothelial cells to produce cell adhesion molecules. Cell adhesion molecules play an important role in the inflammation process by inducing adherence of leukocytes in blood stream to the end...

The purpose of this study was to determine whether the levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) are altered during the second trimester in the plasma of women who subsequently develop preeclampsia. We performed a case-control study to compare the levels of sFlt-1 and PlGF in the preeclamptic (n=46) and normal pregnant women (n=100). The maternal pl...

The aim of this study was to compare the mean platelet volume (MPV) in babies of preeclamptic and normal pregnant women and to investigate the correlation between thrombocytopenia and MPV in the babies of preeclamptic mothers. A total of 63 newborns with similar gestational ages were included in this retrospective study. They were divided into three groups as 21 babies of preeclamptic mothers w...

Upon activation, neutrophils release reactive oxygen species that are believed to contribute to the widespread manifestation of preeclampsia. Neutrophils have an NADPH oxidase enzyme that catalyzes the production of reactive oxygen species. Little is known about the manifestations of the activated response and the upstream signaling pathways that regulate this process in preeclampsia. It is hyp...

Preeclampsia is a significant cause of maternal and fetal morbidity and mortality worldwide. A clinically useful screening test that can predict development of preeclampsia at an early stage is urgently needed. The detection of podocyturia by immunohistochemistry after cell culture has been noted as a reliable marker for preeclampsia. However, this method is laborious and carries the risk of ce...

background: to investigate thyroid function in preeclamptic patients in comparison with normal pregnant women. methods: in this analytical cross-sectional study free thyroxine (t4), and thyroid stimulating hormone (tsh) levels were measured in 100 preeclamptic patients and were compared with free t4 and tsh levels in 101 normal pregnant women in their third trimester of pregnancy. patients with...

background: the aim of this study was to evaluate copper status in women with preeclampsia. materials and methods: sixty preeclamptic, sixty normotensive pregnant and sixty healthy nonpregnant women were enrolled in a cross sectional study. the 24-hour urine copper was compared among the women. results: there was significant difference in the copper concentration of 24-hour urine among the thre...

To better understand the molecular mechanisms involved in pathological development of placenta in preeclampsia, we used LC-MS/MS to construct a large-scale comparative proteome profile of human placentas from normal and preeclamptic pregnancies. A total of 2636 proteins were detected in human placentas, and 171 different proteins were definitively identified between control and preeclamptic pla...