BACKGROUND SYNTAX score (SxS) has been demonstrated to predict long-term outcomes in stable patients with coronary artery disease. But its prognostic value for patients with acute coronary syndrome remains unknown. AIM To evaluate whether SxS could predict in-hospital outcomes for patients admitted with ST elevation myocardial infarction (STEMI) who undergo primary percutaneous coronary inter...

OBJECTIVES Administration of the glycoprotein IIb/IIIa inhibitor abciximab to patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) improves outcome. Data have suggested that an intracoronary (IC) bolus might be superior to the standard intravenous (IV) administration. We have previously reported reduced short-term mortalit...

Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion modality in patients with ST-elevation myocardial infarction (STEMI). While PPCI is highly effective in achieving epicardial coronary reperfusion, a significant proportion of patients fail to achieve adequate myocardial reperfusion. This is in part due to the distal microembolisation of thrombus and plaque debris dur...

BACKGROUND Bioresorbable vascular scaffolds (BVS) represent promising new technology, but data on their long-term outcomes in ST-segment-elevation myocardial infarction (STEMI) setting are missing. The aim was to analyze 1-year clinical and computed tomographic angiographic outcomes after BVS implantation in STEMI. METHODS AND RESULTS PRAGUE-19 is a prospective multicenter single-arm study en...

BACKGROUND We explored the value of admission levels of N-terminal pro-brain natriuretic peptide (NTProBNP) that best predicts poor myocardial tissue perfusion following primary percutaneous coronary intervention (PPCI) in patients admitted with acute ST-segment-elevation myocardial infarction (STEMI). METHODS We enrolled 90 consecutive patients admitted with acute STEMI who underwent PPCI an...

There are a number of unique challenges associated with setting-up and running randomised controlled trials in an emergency setting. Within the NIAMI (Nitrates in Acute Myocardial Infarction) Trial patients present as an emergency and clinicians aim to start primary percutaneous coronary intervention (PPCI) without unnecessary delay. The trial drug is delivered before PPCI is commenced so there...

BACKGROUND SYNTAX score II (SS-II) has been demonstrated to predict long-term outcomes in unprotected left main or multiple vessels in patients with coronary artery disease. However, its prognostic value for patients with ST-segment elevation myocardial infarction (STEMI) remains unknown. The poor myocardial perfusion (myocardial blush grade [MBG] 0/1) after primary percutaneous coronary interv...

Background Whether high platelet reactivity (HPR) at the time of angiography is associated with worse myocardial reperfusion after primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) is unknown. This study aimed to assess the impact of HPR on infarct size and reperfusion injury determined by cardiac magnetic resonance (CMR) in patients with S...

OBJECTIVES The aim of our study was to investigate the feasibility of pPCI in hospital without cardiac surgery, and to compare our "real-world" results to current guidelines and historical controls. METHODS Data of all STEMI patients treated by PCI were prospectively recorded. RESULTS From January 2005 through October 2007, 366 consecutive patients with STEMI were enrolled. In-hospital mort...

Background: Symptom-to-balloon time (SBT) and door-to-balloon (DBT) are both considered important metrics in patients undergoing primary percutaneous coronary intervention (pPCI) for ST-segment–elevation myocardial infarction (STEMI). We sought to assess the relationship of SBT DBT with infarct size microvascular obstruction (MVO) after pPCI. Methods: Individual patient data 3115 pPCI 10 random...