background: recent studies indicate an increased incidence of pertussis disease in recent years. the aim of this study was to evaluate the efficacy of the acellular vaccine for children (as a replacement of current whole cell vaccine in the expanded program on immunization) and for high-risk adults in iran through updating current best available evidence.   methods: we performed a systematic li...

results the results showed that all the strains had the dominant allele ptxs1a. there were differences between the alleles of the clinical strains and the vaccine strain. conclusions in recent years, a significant increase in the incidence of pertussis has been reported worldwide. our findings regarding the allelic shift of the ptxs1 gene are similar to those reported in many european and ameri...

BACKGROUND Parainfectious vascular events are a known complication of bacterial meningitis, typically occurring within two weeks of disease onset. Delayed vascular complications are rare. We present a case of progressive vasculopathy following bacterial meningitis. CASE DESCRIPTION A 20 year old woman developed progressive vasculopathy after successful treatment of pneumococcal meningitis. Wi...

Encephalitis means inflammation of the brain. Acute encephalitis associated with viral infections includes two distinct clinical-pathological diseases. The form referred to simply as acute viral encephalitis is direct infection of neural cells with perivascular inflammation, neuronal destruction, neuronophagia, and tissue necrosis, and this pathology is centered primarily in the gray matter. Th...