See related article, pages 1155–1159 The 20th century witnessed marked improvements in public health and drastic reductions in mortality from common diseases of earlyand midlife leading to a large and growing segment of the population over the age of 65.1 These demographic trends are expected to continue in the coming decades.1 As a result, demographers are forecasting an increase in the number...

BACKGROUND AND PURPOSE Stroke is a major cause of disability in the elderly and is also related to the development of dementia, which is another important source of disability in old age. The aim of the present study was to examine the potential impact of stroke on cognitive and functional status in a community-based cohort of individuals aged 75 years and older. METHODS The data were derived...

OBJECTIVE To assess UK governmental and charity research funding in 2012 for cancer, coronary heart disease (CHD), dementia and stroke, and to make comparisons with 2008 levels. DESIGN Analysis of research expenditure. SETTING United Kingdom. MAIN OUTCOME MEASURES We identified UK governmental agencies and charities providing health research funding to determine the 2012 levels of funding...

We determined the prevalence of dementia in 927 patients with acute ischemic stroke aged greater than or equal to 60 years in the Stroke Data Bank cohort based on the examining neurologist's best judgment. Diagnostic agreement among examiners was 68% (kappa = 0.34). Of 726 testable patients, 116 (16%) were demented. Prevalence of dementia was related to age but not to sex, race, handedness, edu...

BACKGROUND the number of nonagenarians increases dramatically worldwide. OBJECTIVES to examine the prevalence of stroke/transient ischaemic attack (TIA) and dementia, their inter-relationship and their relation to 2-year mortality and institutionalisation in 97 year olds. METHODS a population-based sample of 97 year olds (n=591) was examined. Information on stroke/TIA was obtained from self...

BACKGROUND AND PURPOSE The goal of the present study was to examine a series of putative risk factors of poststroke dementia (PSD), especially those factors usually associated with cerebrovascular disease and degenerative dementia, in a series of 251 consecutive unselected stroke patients. METHODS A standard protocol was prospectively applied at admission and 3 months after stroke; this proto...

BACKGROUND AND PURPOSE A number of cross-sectional epidemiological studies have reported that one fourth of elderly patients meet criteria for dementia 3 months after ischemic stroke, but few longitudinal studies of the incidence of dementia after stroke have been performed. We conducted the present study to investigate the incidence and clinical predictors of dementia after ischemic stroke. ...

large GCH1 mutation positive family with dopa responsive dystonia: confusing the picture? J Neurol Neurosurg Psychiatry 2002; 72: 801–4. Grünewald A, Kasten M, Ziegler A, Klein C. Next-generation phenotyping using the parkin example: time to catch up with genetics. JAMA Neurol 2013; 70: 1186–91. Klepitskaya O, Neuwelt AJ, Nguyen T, Leehey M. Primary dystonia misinterpreted as Parkinson disease:...

PURPOSE This study investigated changes in attitudes toward elders in general and elders with dementia after students finished a gerontological nursing practicum. METHODS Questionnaires developed for Asian cultures were administered pre practicum, immediately post practicum, and at 8-months follow up to 31 senior students in a baccalaureate nursing program. The 1-week practicum occurred at tw...

Background and Purpose—Both stroke and the apolipoprotein E (APOE) e4 allele increase the risk of dementia. However, the interaction between stroke and APOE on dementia is still unclear. We addressed this topic by using a longitudinal design. Methods—We followed up a community cohort of 1301 subjects aged $75 years, who did not have dementia at baseline. Among them, 92 subjects had a history of...