OBJECTIVE To estimate the effect of escitalopram (10-20 mg/d) versus placebo for reducing hot flash interference in daily life and understand correlates and predictors of reductions in hot flash interference, a key measure of quality of life. DESIGN Multisite, randomized, double-blind, placebo-controlled clinical trial. SETTING MsFLASH clinical sites in Boston, Indianapolis, Oakland, and Ph...

With respect to the high incidence of hot flash in postmenopausal women and the controversies regarding its treatment, this double-blind clinical trial was conducted to determine the effects of Pimpinella anisum on hot flashes in these women referring to rural and urban health centers of Qazvin Province in 2009. Seventy-two women with hot flashes were randomly selected according to the predeter...

The gold standard for objectively measuring hot flashes in women is an increased sternal skinconductance level (SCL), but validation studies in prostate cancer patients are lacking. In the laboratory,an SCL increase of ≥1.78 micro-mho in 45 s had a sensitivity of 68% and a positive predictive value of100% in detecting self-reported hot flashes among prostate cancer patients. Out...

OBJECTIVE To test whether more physiologically assessed hot flashes were associated with more connectivity in the default mode network (DMN), the network of brain regions active during rest. We particularly focus on DMN networks supporting the hippocampus as this region is rich in estrogen (E) receptors (ER) and has previously been linked to hot flashes. DESIGN Women underwent 24 hours of phy...

numbers will increase to 60 million in the next 10 years and the attitudes about menopause are continuing to move from being viewed as a clinical syndrome to a natural transition have opened the way for more natural and comprehensive management of menopausal symptoms. This review will discuss the physiological and clinical aspects of menopause, with a view to both the inevitable and preventable...

Background: Hot flash is considered to be an early and common symptom of menopause. This symptom can interfere with the social and personal life of women; therefore, it demands a secure and effective intervention. Therefore, the present study aimed to determine the impact of black cohosh (Cimicifugaracemosa or actaearacemosa) on vasomotor symptoms in postmenopausal women. Materials and Methods:...

vaginal leiomyomas are uncommon benign tumour with variable clinical presentation. these tumours arise most commonly from anterior vaginal wall. we report a case of 50-year old postmenopausal woman who presented with urinary retention, profuse vaginal bleeding and mass protruding into vagina. local examination revealed a pedunculated mass attached to the posterior vaginal wall with vascular sta...

PURPOSE/OBJECTIVES To compare the hot flash symptom experience and related outcomes between breast cancer survivors and healthy women. DESIGN Descriptive, cross-sectional, comparative study. SETTING Southeastern university medical center. SAMPLE 69 of 207 breast cancer survivors contacted via a tumor registry and 63 age-matched healthy female volunteers. Survivors were a mean of 57 years ...

BACKGROUND Use of food supplements-containing phytoestrogens among postmenopausal women is rapidly increasing. Although phytoestrogens are often perceived as safe, evidence for overall positive risk-benefit profile is still inconclusive. The chance to buy them by user's initiative does not facilitate surveys on their prevalence and pattern of use. The aim of this study was to describe the patte...