In this letter, a Hierarchical Parametric Empirical Bayes model is proposed to model spike count data. We have integrated Generalized Linear Models (GLMs) and empirical Bayes theory to simultaneously provide three advantages: (1) a model of over-dispersion of spike count values; (2) reduced MSE in estimation when compared to using the maximum likelihood method for GLMs; and (3) an efficient alt...

Balanced states in large networks are a usual hypothesis for explaining the variability of neural activity in cortical systems. In this regime the statistics of the inputs is characterized by static and dynamic fluctuations. The dynamic fluctuations have a Gaussian distribution. Such statistics allows to use reverse correlation methods, by recording synaptic inputs and the spike trains of ongoi...

15 Auditory receptor neurons of crickets are most sensitive to either low or high 16 sound frequencies. Earlier work showed that the temporal coding properties of first-order 17 auditory interneurons are matched to the temporal characteristics of natural low18 frequency and high-frequency stimuli (cricket songs and bat echolocation calls, 19 respectively). We study the temporal coding propertie...

38 pages, 8 figures, 1 table and 11 equations. The total number of words in: (i) the whole manuscript: 8909. (ii) the Abstract: 164 and (iii) the Introduction: 542. Abstract Weber's law is one of the basic laws in psychophysics, but the link between this psychophysical behavior and the neuronal response has not yet been established. In this paper, we carried out an analysis on the spike train s...

The cerebellum is essential in motor learning. At the cellular level, changes occur in both the simple spike and complex spike firing of Purkinje cells. Because simple spike discharge reflects the main output of the cerebellar cortex, changes in simple spike firing likely reflect the contribution of the cerebellum to the adapted behavior. Therefore, we investigated in Rhesus monkeys how the rep...

Studies in vision show that attention enhances the firing rates of cells when it is directed towards their preferred stimulus feature. However, it is unknown whether other sensory systems employ this mechanism to mediate feature selection within their modalities. Moreover, whether feature-based attention modulates the correlated activity of a population is unclear. Indeed, temporal correlation ...

Glutamate activates a class of receptors coupled to G-proteins that initiate second messenger cascades, change ion channel function, cause release of calcium from intracellular stores, and produce long-term changes in synaptic strength. We used the CA3 region of the adult rat hippocampal slice to evaluate group I metabotropic glutamate receptor (mGluR) activation on epileptiform activity and th...

The planning of goal-directed movements requires sensory, temporal, and contextual information to be combined. Sensorimotor functions are embedded in large neuronal networks, but it is unclear how networks organize their activity in space and time to optimize behavior. Temporal coordination of activity in many neurons within a network, e.g., spike synchrony, might be complementary to a firing r...

VASILEVA, S. and M. MARCHEVA, 2016. Genetic analysis of productivity components in malting barley (Hordeum vulgare, L.) hybrid progenies. Bulg. J. Agric. Sci., 22: 452–457 The investigation was conducted on the experimental fi eld of the Agricultural University of Plovdiv, during the period 2011–2014. Coeffi cients of heritability and selection, the number of genes, transgressions and heterosis...

We report and compare the performance of different learning algorithms based on data from cortical recordings. The task is to predict the orientation of visual stimuli from the activity of a population of simultaneously recorded neurons. We compare several ways of improving the coding of the input (i.e., the spike data) as well as of the output (i.e., the orientation), and report the results ob...