نتایج جستجو برای: pon1 activity

تعداد نتایج: 1134962  

2013
Mohammed Mahmoud Ahmed Eman Mahmoud Elserougy Iman Ibrahim Al-Gazzar Iman Mohamed Fikry Dawoud Fakhry Habib Khaled Mohamed Younes Neveen Abd El-hameed Salem

Systemic lupus erythematosus (SLE) patients have an increased risk of atherosclerosis. Identification of at-risk patients and the pathogenesis of atherosclerosis in SLE remain elusive. Paraoxonase 1 (PON1) and anti-apolipoprotein A-I antibody (anti-Apo A-I) appear to have a potential role in premature atherosclerosis in SLE. The aim of this work was to study PON1 activity and anti-Apo A-I antib...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2012
Jasmin Khateeb Yulia Kiyan Michael Aviram Sergey Tkachuk Inna Dumler Bianca Fuhrman

OBJECTIVE The atherosclerotic lesion is characterized by lipid peroxide accumulation. Paraoxonase 1 (PON1) reduces atherosclerotic lesion oxidative stress, whereas urokinase-type plasminogen activator (uPA) increases oxidative stress in atherosclerotic lesions and contributes to the progression and complications of atherosclerosis. We hypothesized that uPA may promote oxidative stress in the ar...

2016
Do-Sim Park Kyeong Ho Yun Hyun Young Park Sang Jae Rhee Nam-Ho Kim Seok Kyu Oh Jin-Won Jeong

BACKGROUND AND OBJECTIVES The clinical significance of statin-induced high-density lipoprotein cholesterol (HDL-C) changes is not well known. We investigated whether rosuvastatin-induced HDL-C changes can influence the anti-oxidative action of high-density lipoprotein particle. SUBJECTS AND METHODS A total of 240 patients with stable ischemic heart disease were studied. Anti-oxidative propert...

2013
Chiyan Zhou Jia Cao Liang Shang Chuanfeng Tong Hanling Hu Hui Wang Daping Fan Hong Yu

Paraoxonase-1 (PON1), a high-density-lipoprotein- (HDL-) associated enzyme, has the potential to protect against atherogenesis. We examine the relationships between plasma PON1 activity and the progression of atherosclerosis as well as coronary artery disease (CAD). Fasting blood samples were collected from female apolipoprotein E-deficient (apoE(-/-)) mice and 149 patients undergoing coronary ...

Journal: :Acta biochimica Polonica 2010
Marija Macan Nada Vrkić Ana Lucić Vrdoljak Božica Radić Vlasta Bradamante

We investigated the influence of high sucrose diet (HSD) after 3 or 5 weeks of administration on paraoxonase 1 (PON1) activity in plasma of normolipidemic rats and the relationship between serum PON1 activity, triacylglycerides (TGs), HDL and total cholesterol vs. the control group of rats fed normal, control diet (CD). Because the data about the influence of gemfibrozil (GEM) on PON1 activity ...

Journal: :The Journal of biological chemistry 2006
Olga Khersonsky Dan S Tawfik

Serum paraoxonases (PONs) are calcium-dependent lactonases that catalyze the hydrolysis and formation of a variety of lactones, with a clear preference for lipophilic lactones. However, the lactonase mechanism of mammalian PON1, a high density lipoprotein-associated enzyme that is the most studied family member, remains unclear, and other family members have not been examined at all. We present...

2016
Hua Shen

Polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants that have been associated with various adverse health effects in humans and wildlife. Dioxinlike PCBs elicit a broad spectrum of biochemical and toxic changes including cardiovascular disorders. Paraoxonase 1 (PON1), an antioxidant enzyme, prevents oxidative stress and plays key roles in the pathogenesis of atherosclerosis...

Journal: :The Indian journal of medical research 2009
Nidhi Gupta Kirandip Gill Surjit Singh

Paraoxonases (PONs) i.e. PON1, PON2, PON3 are basically lactonases. Of these, PON1 in addition has an efficient esterase activity and can hydrolyze organophosphates. The PONs prevent low density lipoprotein cholesterol (LDL-C) from peroxidation, thereby preventing atherosclerosis. The PON1 is exclusively associated with high density lipoprotein cholesterol (HDL-C) and its antioxidant activity i...

2012
Philip W. Connelly Graham F. Maguire Michelle M. Nash Lindita Rapi Andrew T. Yan G. V. Ramesh Prasad

South Asian renal transplant recipients have a higher incidence of cardiovascular disease compared with Caucasian renal transplant recipients. We carried out a study to determine whether paraoxonase 1, a novel biomarker for cardiovascular risk, was decreased in South Asian compared with Caucasian renal transplant recipients. Subjects were matched two to one on the basis of age and sex for a tot...

Journal: :Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2010
C Boesch-Saadatmandi S Egert C Schrader X Coumoul R Barouki M J Muller S Wolffram G Rimbach

There is increasing evidence that the HDL-associated enzyme paraoxonase 1 (PON1) may have a protective function in the atherosclerotic process. An enhancement of PON1 activity by dietary factors including flavonoids is therefore of interest. Quercetin, a flavonol frequently present in fruits and vegetables has been shown to induce PON1 in cultured liver cells, but the in vivo efficacy of a diet...

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