in the present study ethanol and water extracts of 15 seaweeds, dictyota dichotoma var. velutricata, dictyota indica, iyengaria stellata, padina pavonia, sargassum swartzii, sargassum variegatum, stoechospermum marginatum, stokeyia indica, jolyna laminarioides, caulerpa taxifolia, halimeda tuna, ulva fasciata, ulva lactuca, solieria robusta, and melanothamnus afaqhusainii, were evaluated for th...

The microbial polysaccharide HS-142-1 has been documented as an antagonist of natriuretic peptides. It inhibits activation and peptide binding to both guanylate receptors natriuretic peptide receptor (NPR)-A and NPR-B, but has no effect on the non-cyclase receptor NPR-C. At first sight the effect of HS-142-1 on peptide binding appears to be surmountable, suggesting that it might be competitive ...

1. A substance has been isolated from the venom of the Okinawan pit viper (Trimeresurus okinavensis) that causes the aggregation of human blood platelets. The reaction resembles that between platelets and thrombin or connective tissue, in that the platelets release ADP. 2. The purified venom fraction is a protein-polysaccharide, and after Pronase digestion had mol.wt. 4x10(6), containing 10% pe...

The structure of a complex between the Fab fragment of the antibody (SYA/J6) specific for the cell surface O-antigen polysaccharide of the pathogen Shigella flexneri Y and an octapeptide (Met-Asp-Trp-Asn-Met-His-Ala-Ala), a functional mimic of the O-antigen, has been determined at 1.8-A resolution. Comparison of the structure with that of the complex with the pentasaccharide antigen [-->2)-alph...

Renewable resources can provide a range of different polysaccharide blocks that be used to prepare new types stimuli-responsive polysaccharide-based block copolymers.

Polysaccharide degrading enzymes from commercial T. reesei broth have been subjected to "fingerprint" analysis by high-resolution 2-D gel electrophoresis. Forty-five spots from 11 x 25 cm Pharmacia gels have been analyzed by LC-MS/MS and the resulting peptide sequences were compared to existing databases. Understanding the roles and relationships of component enzymes from the T. reesei cellulas...

1. Heparin, heparan sulphate, chondroitin sulphate and dermatan sulphate were covalently attached to beads of agarose activated by cyanogen bromide. The bond is probably mediated by the amino group of a serine or peptide residue at the reducing end of the polysaccharide chain. 2. The uptake of glycosaminoglycan during the coupling procedure is about 0.9mg/ml of wet gel. However, direct analysis...

Due to rapidly increasing resistance development against conventional antibiotics, as well as problems associated with diseases either triggered or deteriorated by infection, antimicrobial and anti-inflammatory peptides have attracted considerable interest during the last few years. While there is an emerging understanding of the direct antimicrobial function of such peptides through bacterial ...

the role of vi-capsular polysaccharide (vi-cps) in human immunity against infection caused by salmonella typhi is well known. the downstream process of purification generally causes depolymerization of vi-cps to a nonimmunogenic low molecular weight form. in the present study, a standard strain of sal. typhi ty6s was grown under submerge cultural conditions in a pilot-plant scale of 90 liter fe...