The grim prognosis for patients diagnosed with malignant gliomas necessitates the development of new therapeutic strategies for localized and sustained drug delivery to combat tumor drug resistance and regrowth. Here we introduce drug encapsulated aerosolized microspheres as a biodegradable, intelligent glioma therapy (DREAM BIG therapy). DREAM BIG therapy is envisioned to deliver three chemoth...

The influence of abscisic acid (ABA) on carbon metabolism, rate of photorespiration, and the activity of the photorespiratory enzymes ribulose bisphosphate oxygenase and glycolate oxidase in 7-day-old barley seedlings (Hordeum vulgare L. var. Alfa) was investigated. Plants treated with ABA had enhanced incorporation of labeled carbon from (14)CO(2) into glycolic acid, glycine, and serine, while...

Measurements of uptake and mineralization of 14C-labeled glycolic acid by freshwater heterotrophs showed that respiration (mineralization) accounts for 69% of total uptake, and that the heterotrophic potential ( V,,,,, ) for glycolate is comparable with that for other commonly used substrates. Bacteria cultured from lake water showed uptake and mineralization patterns similar to those from the ...

Design of mechanical skeletons of biodegradable synthetic polymers such as poly(L-lactic acid) (PLLA), poly(DL-lactic-co-glycolic acid) (PLGA), and poly(ε-caprolactone) (PCL) is important in the construction of the hybrid scaffolds of biodegradable synthetic polymers and naturally derived polymers such as collagen. In this study, cylinder-shaped PLLA, PLGA, and PCL sponges were prepared by the ...

Abstract: Aim: This article describes how biodegradable polymers and their drug delivery mechanisms can be used to monitor maintain local or targeted distribution. Polylactic-co-glycol acid has been one of the most appealing polymeric candidates for creating release tissue engineering products over last couple decades. PLGA a variety purposes due its biodegradability biocompatibility. Materials...

Nifedipine is a hypertension drug must be consumed three times a day due to its low oral bioavailability. One way of developing a controlled drug delivery system is making nifedipine microcapsules by using environmentally friendly polymers of polylactic acid and polycaprolactone via the evaporation method using oil-in-water solvents. Polylactic acid and polycaprolactone can be said to be enviro...

Targeted drug delivery to endothelial cells lining the vasculature can improve treatment of many pathologies. Intercellular adhesion molecule-1 (ICAM-1), a transmembrane glycoprotein overexpressed in many diseases, is a good determinant for endothelial targeting of drug nanoparticles (NPs). In this study we synthesized surfactant-free, FITC-labeled poly(lactic-co-glycolic) acid (PLGA) NPs coate...

BACKGROUND The therapeutic strategies for malignant melanoma are still cancer chemotherapy, radiotherapy, and tumor resection. However, these therapeutic strategies often lead to a reduced neutrophilic granulocyte count or loss of more blood after surgical tumor resection. In this study, we developed a formulation of hemostatic gauze impregnated with sustained-release granulocyte colony-stimula...

UNLABELLED BACKGROUND.: Microvascular free tissue transfer has become increasingly popular in the reconstruction of head and neck defects, but it also has its disadvantages. Tissue engineering allows the generation of neo-tissue for implantation, but these tissues are often avascular. We propose to combine tissue-engineering techniques together with flap prefabrication techniques to generate a ...

The aim of the present study is to evaluate the potential differentiation ability of gingiva originated human mesenchymal stem cell in the presence of tacrolimus. Tacrolimus-loaded poly(lactic-co-glycolic acid) microspheres were prepared using electrospraying technique. In vitro release study of tacrolimus-loaded poly(lactic-co-glycolic acid) microspheres was performed in phosphate-buffered sal...