نتایج جستجو برای: polygenic dyslipidemia
تعداد نتایج: 16254 فیلتر نتایج به سال:
Structural brain magnetic resonance imaging (MRI) traits share part of their genetic variance with cognitive traits. Here, we use genetic association results from large meta-analytic studies of genome-wide association (GWA) for brain infarcts (BI), white matter hyperintensities, intracranial, hippocampal, and total brain volumes to estimate polygenic scores for these traits in three Scottish sa...
background: diabetes mellitus (dm) is closely associated with reduction of antioxidant defense system. in the present study, we investigated the antioxidant effect of quercetin supplementation on the glycemic control, lipid profile and oxidative stress indices in patients with type 2diabetes. methods: forty seven patients with type 2 diabetes, aged 30-60 years old, were randomly assigned to sup...
IMPORTANCE Schizophrenia has a complex etiology influenced both by genetic and nongenetic factors but disentangling these factors is difficult. OBJECTIVE To estimate (1) how strongly the risk for schizophrenia relates to the mutual effect of the polygenic risk score, parental socioeconomic status, and family history of psychiatric disorders; (2) the fraction of cases that could be prevented i...
The classical model of mutation-selection balance for quantitative characters sums the effects of individual sites to determine overall character value. I develop an alternative version of this classical model in which character value depends on the averaging of the effects of the individual sites. In this new averaging model, the equilibrium patterns of variance in allelic effects and characte...
BACKGROUND Coronary artery disease (CAD) is associated with cognitive decrements and risk of later dementia, but it is not known if shared genetic factors underlie this association. We tested whether polygenic risk for CAD was associated with cognitive ability in community-dwelling cohorts of middle-aged and older adults. METHODS Individuals from Generation Scotland: Scottish Family Health St...
Introduction: Mortality rates in patients with schizophrenia and bipolar disorder are higher than the general population. Cardiovascular disease is the most important of natural cause of death in these patients. The aim of this study was to assess the prevalence of dyslipidemia and some of related factors in these patients. Methods: We conducted an analytic cross-sectional study on 200 subject...
OBJECTIVE The study investigated whether childhood cognitive ability moderates Type 2 diabetes polygenic risk manifestation in older age. METHOD In 940 relatively healthy people (mean age 69.55 ± 0.85), we tested whether self-reported diabetes and hemoglobin HbA1c (HbA1c) levels were predicted by diabetes polygenic risk, cognitive ability measured about 60 years earlier, and their interaction...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید