A utosomal dominant polycystic kidney disease (ADPKD) is a genetic condition characterised by the formation of multiple fluid-filled renal cysts and kidney enlargement. Potential complications of ADPKD include adult-onset end-stage kidney disease, early-onset hypertension and nephrolithiasis. ADPKD is also associated with systemic conditions including intracranial cerebral aneurysm and polycyst...

autosomal dominant polycystic kidney disease (adpkd) is the most common genetic nephropathy, which is characterized by replacement of renal parenchyma with multiple cysts. in iran, the disease prevalence within the chronic hemodialysis patient population is approximately 8-10%. so far, three genetic loci have been identified to be responsible for adpkd. little information is available concernin...

All components of the endothelin (ET) system are present in renal tubular cells. In this review, we summarize current knowledge about ET and the most common tubular diseases: acute kidney injury (AKI) and polycystic kidney disease. AKI originally was called acute tubular necrosis, pointing to the most prominent morphologic findings. Similarly, cysts in polycystic kidney disease, and especially ...

An 81-year-old gentleman with chronic kidney disease presented with pyrexia and a new systolic cardiac murmur. Investigations revealed infective aortitis of a pre-existing aortic aneurysm graft repair. Peripheral blood cultures were positive for Yersinia pseudotuberculosis and the patient was successfully treated with an extended course of antibiotics. Abdominal imaging also revealed progressiv...

Recessive (infantile) polycystic kidney disease is a rare inherited disorder with cystic dilations of the renal collecting ducts frequently associated with hepatic involvement. The gene responsible for this disease, PKHD1, located on the short arm of chromosome 6, has recently been identified. Autosomal recessive polycystic kidney disease is a rare entity with an incidence of 1:10,000 to 1:40,0...