poly methyl methacrylate (pmma) is the most common material used in prosthodontics. several studies indicate a breakdown of the number of very high resin bases after 2 to 3 years to avoid breaking bass and several attempts have been made, such as altering the chemical structure of resin by adding causes cross linking or copolymerization. the innovative method for improving the physical properti...

A peptide derived from p34cdc2, cdc2(6-20)NH2 with the amino acid sequence of KVEKIGEGTYGVVYK-amide, was found to be a specific and efficient substrate for a pp60c-src-related protein tyrosine kinase from bovine spleen (STK). Glu-12 and Thr-14 were identified to be substrate specificity determinants in this peptide (Cheng, H.-C., Litwin, C. M. E., Hwang, D. M., and Wang, J. H. (1991) J. Biol. C...

The self-assembly in aqueous solution of three novel telechelic conjugates comprising a central hydrophilic polymer and short (trimeric or pentameric) tyrosine end-caps has been investigated. Two of the conjugates have a central poly(oxyethylene) (polyethylene oxide, PEO) central block with different molar masses. The other conjugate has a central poly(L-alanine) (PAla) sequence in a purely ami...

Protein tyrosine phosphatases (PTPases) regulate the tyrosine phosphorylation of target proteins in‌volved in several biological activities including cell proliferation and transformation. Protein tyrosine phosphatase E (PTPE) contains duplicated PTPase-like domains and a short extracellular region. Us‌ing the fluorescence in situ hybridization method, the gene encoding PTPE (locus symbol Ptpre...

High-vacuum polymerization of R-(amino acid)-N-carboxyanhydrides (NCAs) affords polymers with controlled molecular weights and narrow polydispersities; however, a comprehensive study of the end-group composition of the resulting polypeptides has not yet been performed. This reveals crucial information, as the end-groups are indicative of both the polymerization mechanism (i.e., initiation event...

The inhibitory influence of various acidic macromolecules on the enzymatic activity of bovine pancreatic ribonuclease has been studied extensively in recent years. Heparin (l-5) as well as other sulfated polysaccharides (5-7)) synthetic polysaccharide macroanions (8, 9), polyphloretin phosphate (4, lo), polyxenyl phosphate (ll), and acidic polymers related to humic acids (12) are among the inhi...

Voclosporin is a highly potent, new cyclosporine-A derivative that is currently in Phase 3 clinical trials in the USA as a potential treatment for inflammatory diseases of the eye. Voclosporin represents a number of very sparingly soluble drugs that are difficult to administer. We therefore selected it as a model drug that is dispersed within amphiphilic polymer matrices, and investigated the c...

ANG II rapidly increases VEGF synthesis in proximal tubular epithelial cells through mRNA translation. The role of heterogeneous nuclear ribonucleoprotein K (hnRNP K) in ANG II regulation of VEGF mRNA translation initiation was examined. ANG II activated hnRNP K as judged by binding to poly(C)- and poly(U)-agarose. ANG II increased hnRNP K binding to VEGF mRNA at the same time as it stimulated ...

It is axiomatic that efficient crystal production reflects upon the quality of structure. An empirical relation for mass proportions of two solvents in crystallization of Z-Tyr-Gly-OEt shows a linear relationship. The dipeptide crystallizes in orthorhombic space group P212121, with cell parameters a=5.0680(1)Å, b=13.8650(1)Å and c=28.2630(1)Å, Z=4, Dcalc= 1.339Mg/m , μ=0.820mm-, F000=848, CuKα ...