In Sweden as well as in many other countries most materials currently used for dental restorations contain acrylate and methacrylate monomers (1). As a consequence of increased use of resin-based compounds, there has been an increase in reported cases of irritant and allergic contact dermatitis mainly among dental professionals (2-5). The most common agent causing dermatitis among dental profes...

Insight in the osmotic behavior of degrading hydrogels is of great importance in the design of biodegradable hydrogels for biomedical applications. This study compares the degradation behavior of PEG-HEMA (hydroxyethylmethacrylated polyethylene glycol) and dex-HEMA (hydroxyethylmethacrylated dextran) hydrogels. The degradation of PEG-HEMA gels takes several months to over a year, while that of ...

The effectiveness of the antimicrobial peptide maximin-4, the ultrashort peptide H-Orn-Orn-Trp-Trp-NH(2), and the lipopeptide C(12)-Orn-Orn-Trp-Trp-NH(2) in preventing adherence of pathogens to a candidate biomaterial were tested utilizing both matrix- and immersion-loaded poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels. Antiadherent properties correlated to both the concentration rele...

The mechanical fracture of polymer produces polymeric free radical chain-ends, by which liner block copolymers have been synthesized. A diblock copolymer of microcrystalline cellulose (MCC) and poly 2-hydroxyethyl methacrylate (pHEMA) was produced by the mechanochemical polymerization under vacuum and room temperature. The fraction of pHEMA in MCC-block-pHEMA produced by the mechanochemical pol...

Because Methacrylic monomers are used in dental work, dental personnel, technicians, and patients are at risk of being sensitized. 2-hydroxyethyl methacrylate (2-HEMA) and ethyleneglycol dimethacrylate (EGDMA) are commonly used. Allergic test reactions to them sometimes appear beyond D7. This study was designed to study the development and course of positive test reactions to 2-HEMA and EGDMA i...

In Salmonella typhimurium and Escherichia coli, the hemA gene encodes the enzyme glutamyl-tRNA reductase, which catalyzes the first committed step in heme biosynthesis. We report that when heme limitation is imposed on cultures of S. typhimurium, glutamyl-tRNA reductase (HemA) enzyme activity is increased 10- to 25-fold. Heme limitation was achieved by a complete starvation for heme in hemB, he...

The Escherichia coli hemA gene, essential for the synthesis of 5-aminolevulinic acid (ALA), was isolated and sequenced. The following criteria identified the cloned gene as hemA. (i) The gene complemented a hemA mutation of E. coli. (ii) The gene was localized to approximately 26.7 min on the E. coli chromosomal linkage map, consistent with the location of the mapped hemA locus. Furthermore, DN...

The water-soluble HEMA has polar properties with small dimension to enhance the wetting properties of the adhesive solution and the penetration efficacy of the adhesive into demineralized dentin [3]. HEMA has been reported to be positively influence bond strength to dentin. Because of its hydrophilic character, it is also frequently added to improve miscibility of hydrophobic and hydrophilic co...