Recombinant coagulation factor VIII (r-VIII SQ) was chemically modified with monomethoxy poly(ethylene glycol) (mPEG). Three mPEG derivatives were used for coupling to the r-VIII SQ lysines, a mixed anhydride of monomethoxy poly(ethylene glycol) succinic acid (mPEG-SAH), monomethoxy poly(ethylene glycol) succinimidyl succinate (mPEG-SS), and monomethoxy poly(ethylene glycol) tresylate (mPEG-TRE...

Herein, we report the self-assembly and salt-induced thermoresponsive properties of amphiphilic random terpolymers consisting hydrophilic poly(ethylene glycol) (PEG) quaternary ammonium cations, hydrophobic dodecyl groups in water.

Small-angle neutron scattering (SANS) has been used to investigate the solution properties of four model polymers, two poly-amino acids [poly(lysine) and poly (proline)], and two water-soluble synthetic polymers [poly (acrylic acid) and poly(ethylene oxide)]. In each case, one of the two polymers is charged, while the other is neutral. SANS measurements were made in the semi-dilute concentratio...

Gels prepared from metal containing ionic liquids with cross-linked poly(ethylene glycol) have surface compositions and mechanical properties that can be controlled by Lewis basicity acidity of the species.

Stable tethering of bioactive peptides like RGD to surfaces can be achieved via chemical bonding, biotin streptavidin interaction, or photocross-linking. More challenging is the immobilization of proteins, since methods applied to immobilize peptides are either not specific or versatile enough or might even compromise the protein's bioactivity. To overcome this limitation, we have employed a sc...

Novel complexation hydrogel nanospheres of poly(methacrylic acid-grafted-poly(ethylene glycol)) (P(MAA-gEG)) were prepared by dispersion polymerization to be used for protein delivery applications. Polymerization was conducted in solvents such as deionized water, ethanol/water, sodium hydroxide, hydrochloric acid, and acetic acid solutions. When polymerizing in deionized water we produced nanos...

O ur laboratory has developed a number of novel synthetic scaffold materials based on fumaric acid for an assortment of tissue engineering applications. These biodegradable materials include poly(propylene fumarate) (PPF), poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)), and oligo(poly(ethylene glycol) fumarate) (OPF), each of which can be applied as an injectable liquid and crosslink...