To determine Zidovudine (AZT) and Lamivudine (3TC) at the same time based on PAMAM dendrimer modified with Pluronic F127, application as anti-HIV drug control. A fast, accurate HPLC-PDA determination of AZT 3TC high reliability selectivity has been developed validated according to ICH (International Conference Harmonisation Technical Requirements for Registration Pharmaceuticals Human Use) guid...

BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility. The objective of current work was to screen the suitability of glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn the bioavailability of tenofovir disoproxil fumarate (TDF), a BCS class III drug. Spray-drying method was ...

Tri-block copolymers (poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide), represented as EOxPOyEOx), pluronics (F127 = EO106PO70EO106, P65 = EO20PO30EO20, P85 = EO27PO39EO27, P103 = EO17PO55EO17, and P123 = EO20PO70EO20) and cationic surfactants (cethyltrimethylammonium bromide (CTAB)), two surfactant systems, form complex micelles that self-assemble into mesostructured particles w...

The purpose of this study was to prepare a temperature-sensitive gel containing silver nanoparticles and to investigate its anti-bacterial properties in vitro. The aqueous gel was prepared using Pluronic F127 (18-22%) and Pluronic F68 (3-9%) in a cold method to obtain a proper gelation temperature at 37 degrees C. Viscoelastic properties of the system were measured by rheological measurements a...

Copolymers, particularly Pluronics®, are typically used to sterically stabilise colloidal nanostructured particles composed of a lyotropic liquid crystalline bicontinuous cubic phase (cubosomes). There is a need to design and assess new functionalisable stabilisers for these colloidal drug delivery systems. Six amphiphilic brush copolymers, poly(octadecyl acrylate)-block-poly(polyethylene glyco...

Purpose: The aim of the present study was to formulate and evaluate miconazole nitrate containing thermosensitive bioadhesive gel for vaginal drug delivery to achieve a better therapeutic efficacy and patient compliance in the treatment for vaginal candidiasis. Method: Here miconazole nitrate (1%) was formulated as a vaginal gel using thermosensitive polymer, pluronic F127 (20%) along with bioa...

Herein, we explore the idea of self-assembly of nearly monodisperse nanoparticles as uniform building blocks to design highly crystalline mesoporous TiO(2) nanoparticles, through evaporation-induced self-assembly (EISA) and hydrothermal methods by using non-ionic Pluronic F127 and anionic surfactant SDS, respectively as structure directing agents. The small- and wide-angle powder X-ray diffract...

Surfactant or block copolymer-templated mesoporous films have been extensively explored, but achieving mesostructure coherence and unidirectional orientation over macroscopic dimensions has remained quite challenging for these self-assembled systems. Here, we extend the concepts associated with zone refinement of crystalline materials to soft templated mesoporous carbon films based on the coope...

Due to the high complexity of some treatments, there is a need develop drug-delivery systems that can release multiple drugs/bioactive agents at different stages treatment. In this study, thermoresponsive injectable dual-release system was developed with gellan gum/alginate microparticles (GG:Alg) within Pluronic hydrogel composed mixture F127 and F68. The increase in F68 ratio decrease lead hi...