In the present study Thermo and P responsive smart polymers were utilized to overcome the problems encountered for the ophthalmic formulation which normally get drained,short ocular residence once instilled by formulating the smart ophthalmic gels that shows Newtanion flow easy to administer the same get transformed in to gel on contact with eye site due to lachrymal P and physiologic temperatu...

BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility. The objective of current work was to screen the suitability of glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn the bioavailability of tenofovir disoproxil fumarate (TDF), a BCS class III drug. Spray-drying method was ...

Cationic polymers are one of the major nonviral gene delivery vectors investigated in the past decade. In this study, we synthesized several cationic copolymers using atom transfer radical polymerization (ATRP) for gene delivery vectors: pluronic F127-poly(dimethylaminoethyl methacrylate) (PF127-pDMAEMA), pluronic F127-poly (dimethylaminoethyl methacrylate-tert-butyl acrylate) (PF127-p(DMAEMA-t...

Due to the high incidence and mortality rates of cancer, it is necessary seek more targeted effective treatment methods. Traditional cancer methods have problems such as incomplete significant side effects. In recent years, photothermal therapy (PTT) has been considered one most promising in biomedical field. The principle PTT use materials with conversion efficiency absorb near-infrared light ...

Article history: Received on: 07/11/2012 Revised on: 29/12/2012 Accepted on: 22/01/2013 Available online: 28/02/2013 The aim of this research is to develop thermo sensitive drug vehicles for glaucoma therapy in in-situ form to overcome the problems of poor bioavailability, naso lachrymal drainage and rapid precorneal elimination exhibited by conventional eye drops. Thermo sensitive ophthalmic d...

Biochanin A (BCA), a natural dietary isoflavone, has been reported to show anticancer activities. However, its low biological availability and poor aqueous solubility limit its usefulness as a chemotherapeutic agent. We developed BCA-loaded micelles with Pluronic F127 and Plasdone S630 (BCA-FS). The optimized, spherical-shaped BCA-FS was obtained at a ratio of 1:1 (F127:S630). The particle size...