This work reports the feasibility of caffeic acid grafted PLGA (g-CA-PLGA) to design biodegradable sterile microspheres for the delivery of proteins. Ovalbumin (OVA) was selected as model compound because of its sensitiveness of γ-radiation. The adopted grafting procedure allowed us to obtain a material with good free radical scavenging properties, without a significant modification of Mw and T...

the aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates spion and gemcitabine in plga±peg to form multifunctional drug delivery system. for this aim, super paramagnetic iron oxide nanoparticles (spions) were synthesized and encapsulated simultaneously with gemcitabine (gem) in plga±peg copolymers via w/o/w double emulsification method. optimum size and enca...

BACKGROUND AND THE PURPOSE OF THE STUDY Amphotericin B (AmB) which is an appropriate antibiotic for the treatment of mycosis has many toxic effects including nephrotoxicity. Recently preparation of a new drug loaded nanoparticles for the reduction of toxicity and increase in the effectiveness of AmB has been reported. The objective of this study was to prepare and evaluate in vitro and in vivo ...

We utilized a thermal radiation method to synthesize semiconducting hollow ZnO nanoballoons and metal-semiconductor concentric solid Zn/ZnO nanospheres from metallic solid Zn nanospheres. The chemical properties, crystalline structures, and photoluminescence mechanisms for the metallic solid Zn nanospheres, semiconducting hollow ZnO nanoballoons, and metal-semiconductor concentric solid Zn/ZnO ...

Ratio blends of PLGA/PCL: (0:10), (1:9), (2:8), (3:7), (4:6), (5:5), (6:4), (7:3), (8:2), (9:1), and (10:0) were spin-coated to produce thin films; surface topographies were determined using interferometric microscopy. It was demonstrated that micro-wells of a defined size (150 mm) were present in all PCL dominant PLGA/PCL systems. Stratification of PLGA with PCL enabled the formation of that s...

An effective light-harvesting scheme for InGaN-based multiple quantum well solar cells is demonstrated using stacking layers of polystyrene nanospheres. Light-harvesting efficiencies on the solar cells covered with varied stacks of nanospheres are evaluated through numerical and experimental methods. The numerical simulation reveals that nanospheres with 3 stacking layers exhibit the most impro...

The aim of this study was to evaluate the effect of PLGA microsphere dimensions on bone formation after injection of calcium phosphate cement (CPC)/PLGA in a guinea pig tibial intramedullarly model. To this end, injectable CPC/PLGA formulations were prepared using PLGA microspheres with either a small (~25 µm) or large (~100 µm) diameter, which were incorporated at a 20:80 ratio (wt%) within ap...

PURPOSE To compare human urothelial and smooth muscle cells attachment and proliferation using three different matrices; poly lactic-co-glycolic acid (PLGA), PLGA/collagen and human amniotic membrane (hAM). MATERIALS AND METHODS Human urothelial and smooth muscle cells were cultured and examined for expression of urothelium (pancytokeratin and uroplakin III) and smooth muscle cells [desmin an...

This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-coglycolide) (PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology of the PLGA microparticles were also determined. A cytotoxicity test was perform...

The synthesis of polyaniline (PANI) nanospheres by a simple template-free method has been described. The polymerization of aniline in aqueous medium was accomplished using ammonium persulfate without any protonic acid. The UV-vis spectrum of PANI nanospheres displayed the characteristic absorption peak of π-π* transition of the benzenoid ring at 355 nm. The oxidation state of PANI nanospheres w...