نتایج جستجو برای: plasma acylcarnitine profile
تعداد نتایج: 564619 فیلتر نتایج به سال:
Background and purpose: The rate of carbohydrate absorption after a meal, as quantified by glycemic index, has an effect on postprandial hormonal and metabolic response. The aim of the present study is to determine the effects of low-glycemic index diet, versus low-fat diet on the body weight, BMI, WHR (waist/hip ratio) and plasma lipid profile of obese patients. Materials and methods: ...
Patients with symptomatic peripheral arterial occlusive disease have a claudication-limited peak exercise performance that is improved with exercise training. The effects of training on skeletal muscle metabolism were evaluated in 26 patients with claudication, randomized into a 12-wk program of treadmill training (enhances muscle metabolic activity in normal subjects), strength training (stimu...
The purpose of this study was to investigate the cellular distribution of carnitine and its acyl derivatives in the normal and ischemic myocardium, and the effects of exogenous 1-carnitine on this distribution and mitochondrial function in the ischemic dog heart. Under non-ischemic conditions, about 93% of the total cellular carnitine was located in the cytosolic compartment and 6.5% in the mit...
BACKGROUND Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of acylcarnitines. METHODS Patients undergoing successful LAAC were enrolled pro...
The cumulative effects of hepatic injury due to hepatitis B virus (HBV) infections and aflatoxin-B1 (AFB1) exposure are the major risk factors of HCC. Understanding early metabolic changes involving these risk factors in an animal model closely resembling human hepatocellular carcinoma (HCC) is critical for biomarker discovery and disease therapeutics. We have used the hepatitis B surface antig...
Methylmalonyl-coA epimerase (MCE) follows propionyl-coA carboxylase and precedes methylmalonyl-coA mutase in the pathway converting propionyl-coA to succinyl-coA. MCE deficiency has previously been described in six patients, one presenting with metabolic acidosis, the others with nonspecific neurological symptoms or asymptomatic. The clinical significance and biochemical characteristics of this...
The study included 31 patients (5 women and 27 men) aged from 26 to 60 years (44.6± 8.9) and 32 healthy subjects (15 women and 17 men) aged 22-60 years (39.8± 9.4). The patients’ alcohol dependence ranged from 2 to 30 years (13.6± 7.5). Examined subjects consumed 75-700 g of ethanol/day (226.9± 151.5). Plasma concentrations of free and total carnitine were measured three times: at the first (T0...
Incomplete β-oxidation of fatty acids in mitochondria is a feature of insulin resistance and type 2 diabetes mellitus (T2DM). Previous studies revealed that plasma concentrations of medium- and long-chain acylcarnitines (by-products of incomplete β-oxidation) are elevated in T2DM and insulin resistance. In a previous study, we reported that mixed D,L isomers of C12- or C14-carnitine induced an ...
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