Abstract Background Treatments for MDD that can improve both overall depressive and anhedonic symptoms are urgently needed. AXS-05 (dextromethorphan-bupropion) is a novel, oral, investigational NMDA receptor antagonist with multimodal activity being developed MDD. The dextromethorphan component of an sigma-1 agonist. bupropion serves primarily to increase the bioavailability dextromethorphan. O...

Tezepelumab is a human monoclonal antibody that targets thymic stromal lymphopoietin (TSLP). NAVIGATOR evaluated the efficacy and safety of tezepelumab in adults adolescents with severe, uncontrolled asthma. was phase 3, multicenter, randomized, double-blind, placebo-controlled study (NCT03347279). Patients (12-80 years old) asthma were randomized 1:1 to receive 210mg subcutaneously or placebo ...

Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol efflux, mediated by apolipoprotein A-I, removes excess cholesterol from atherosclerotic plaque and transports it to the liver excretion. Impaired efflux is associated with higher cardiovascular (CV) event rates among both stable coronary artery disease recent MI. CSL112, a novel intravenous formulati...

conclusions eps 7630 was found to be efficacious in the treatment of acute tonsillopharyngitis in children and was very well tolerated. methods in this double-blind placebo-controlled clinical trial with a group sequential design, the efficacy and tolerability of eps 7630 were investigated in 6- to 10-year-old patients with acute tonsillopharyngitis, who showed no evidence of group a β-hemolyti...

Community-acquired Pneumonia (CAP) is an infection of the lung parenchyma that acquired outside hospital, [1] involved approximately 150 million new cases annually, among children younger than 5 years old worldwide. We retrospectively evaluated effect Prednisolone in 89 with CAP who were admitted to 2nd hospital Shandong University (China) and Infectious diseases Andijon region (Uzbekistan). Th...

Aims CONCERT-HF is an NHLBI-sponsored, double-blind, placebo-controlled, Phase II trial designed to determine whether treatment with autologous bone marrow-derived mesenchymal stromal cells (MSCs) and c-kit positive cardiac (CPCs), given alone or in combination, feasible, safe, beneficial patients heart failure (HF) caused by ischaemic cardiomyopathy. Methods results Patients were randomized (1...

Abstract Study question Does treatment of abnormal vaginal microbiota improve the reproductive outcomes IVF patients? Summary answer Data is being analysed and will be presented at ESHRE 2023. What known already An increasing number studies reported an association between genital tract adverse in patients. One hypothesis could that ascend to endometrium where hampers implantation. To best our k...

Aims, Objectives and Background Corticosteroids can be used to treat idiopathic facial paralysis (Bell’s palsy) in children, but their effectiveness is uncertain. Aims To determine if prednisolone improves recovery of children with Bell’s palsy at one month. Method Design Double-blind, placebo-controlled, randomised, trial presenting ED palsy. 1 Patients 6 months <18 years, recruited <72 ...

Vitamin D deficiency is associated with cardiovascular and metabolic diseases. Cardiovascular diseases, in turn, are responsible for mortality of patients with type 2 diabetes (T2D). We investigated whether a single parenteral dose of 25(OH) Vit D could improve the endothelial function in T2D patients with ischemic heart disease. A randomized, placebo-controlled, and double-blind trial was perf...