BACKGROUND Complex regional pain syndrome (CRPS) following stroke aggravates morbidity. CRPS is categorized as CRPSI when no clear nerve injury is defined, and CRPSII when associated with clear nerve injury. AIM To compare the effect of prednisolone with that of piroxicam in patients with CRPSI following stroke. DESIGN Randomized controlled trial. METHODS Patients with CRPSI fulfilling th...

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that commonly used for arthritis, gout, and other musculoskeletal disorders. poorly soluble in water according to the biopharmaceutical classification system (BCS) classified as Class II with good permeability but poor dissolution. The self-nanoemulsifying delivery (SNEDDS) has been extensively employed improve dissolution absorption o...

Solid dispersions of a poorly water-soluble drug piroxicam in polyvinylpyrrolidone (PVP) were prepared by precipitation with compressed antisolvent (PCA) and spray drying techniques. Physicochemical properties of the products and drug-polymer interactions were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, and differential scanning calorimetry, etc. Piroxica...

A fast and robust RP-HPLC isocratic method was developed for determination of piroxicam in bulk materials and pharmaceutical formulations. Optimum separation of piroxicam and stress induced degradation a product was achieved using a SB-C18 Eclipse column (150x4.6; 5μm). The mobile phase was a mixture of water: acetonitrile (50:50) with a flow rate of 0.5mL/min. The UV detection was performed at...

Background Nonsteroidal antiinflammatory drugs (NSAIDs) and antibiotics are widely used drugs and are the leading causes of adverse drug reaction (ADR), especially skin reactions. The photosensitizing effects of piroxicam are known for a long time and triggered by a photoproduct structurally similar to antigenic thiosalicylic acid present in the chemical formula of thimerosal and piroxicam. The...

Solid-state properties of piroxicam benzoate, an ester prodrug of piroxicam, were investigated. Samples were prepared by recrystallization from various organic solvents (toluene, ethanol, methanol, ethyl acetate and acetone). Recrystallized samples were characterized by means of FTIR, DSC, TGA, SEM and XRPD. DSC, TGA and XRPD methods confirmed that piroxicam benzoate crystallized in two pseudop...

Piroxicam belongs to BCS class II and has low solubility. Self-nanoemulsifying drug delivery systems (SNEDDS) are considered a potential approach for increasing the solubility release of piroxicam. This study aimed select components component ratios piroxicam SNEDDS using fractional factorial design 26-2 (FFD). The variables used in DFT development type concentration oil (triacetin oleic acid),...

Although NSAIDs are very effective drugs, their use is associated with a broad spectrum of adverse reactions in the liver, kidney, cardiovascular (CV) system, skin and gut. Gastrointestinal (GI) side effects are the most common and constitute a wide clinical spectrum ranging from dyspepsia, heartburn and abdominal discomfort to more serious events such as peptic ulcer with life-threatening comp...

BACKGROUND Targeted drug delivery to colon would ensure direct treatment at the disease site, decrease in dose administration and reduction side effects improved drug utilization. OBJECTIVE The purpose of this research was to decrease gastric side effects of piroxicam by formulating microspheres of alginate and algino-pectinate beads of the drug. MATERIALS AND METHODS Ionotropic gelation wa...