نتایج جستجو برای: piperacillin

تعداد نتایج: 2563  

2010
Marie-Laure Joly-Guillou Marie Kempf Jean-Didier Cavallo Monique Chomarat Luc Dubreuil Jeanne Maugein Claudette Muller-Serieys Micheline Roussel-Delvallez

BACKGROUND Meropenem is a carbapenem that has an excellent activity against many gram-positive and gram-negative aerobic, facultative, and anaerobic bacteria. The major objective of the present study was to assess the in vitro activity of meropenem compared to imipenem and piperacillin/tazobactam, against 1071 non-repetitive isolates collected from patients with bacteremia (55%), pneumonia (29%...

Journal: :The Journal of antimicrobial chemotherapy 2005
Chonghua Li Joseph L Kuti Charles H Nightingale Debra L Mansfield Adrian Dana David P Nicolau

OBJECTIVES We investigated the population pharmacokinetics and pharmacodynamics of piperacillin and tazobactam in hospitalized patients. PATIENTS AND METHODS A multicentre, randomized clinical trial was conducted in hospitalized patients with complicated intra-abdominal infection. Patients received piperacillin/tazobactam administered by either continuous infusion (13.5 g over 24 h, n = 130) ...

Journal: :Antimicrobial agents and chemotherapy 1980
G L Simon D R Snydman F P Tally S L Gorbach

A total of 20 serious infections were treated with piperacillin. These infections included bacteremias (5), pneumonias (5), urinary tract infections (5), soft tissue infections (3), septic arthritis (1), and osteomyelitis (1). The most common bacterial pathogen was Pseudomonas aeruginosa, accounting for eight infections. The clinical and bacteriological response rates were 75 and 70%, respectiv...

2014
Ryan Urbas Raxitkumar Patel Arka Banerjee

A 61-year-old female with past medical history of maculopapular rash reaction to ciprofloxacin and amoxicillin being treated for diverticulitis develops the same rash with administration of piperacillin/tazobactam and aztreonam. A diffuse maculopapular rash developed after the administration of piperacillin. It resolved with discontinuation of the drug and the patient was switched to aztreonam ...

Journal: :The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2009
Melissa Orzechowski Xavier Alessandro Comarú Pasqualotto Valério Rodrigues Aquino Teresa Cristina Teixeira Sukiennik Luiz Carlos Severo

Piperacillin-tazobactam is a broad spectrum antimicrobial agent that can cause false-positive results in the commercial Platelia Aspergillus EIA test. So far, no study has been performed in Latin America to evaluate the clinical implication of this finding. Here we studied the potential for galactomannan detection in piperacillin-tazobactam batches commercialized in the Brazilian market. Five b...

Journal: :Thorax 1981
G E Marlin K R Burgess J Burgoyne G R Funnell M D Guinness

Bronchial mucosal biopsies were obtained during fibreoptic bronchoscopy in 12 patients receiving a new semisynthetic penicillin, piperacillin. The piperacillin levels estimated in bronchial mucosa exceeded those required to eradicate organisms associated with acute bronchitis, Haemophilus influenzae and Streptococcus pneumoniae, and compared favourably with those required for activity against a...

Journal: :Antimicrobial agents and chemotherapy 1978
G P Bodey B Le Blanc

The in vitro activity of a new semisynthetic penicillin, piperacillin, was determined against 577 clinical isolates of gram-positive cocci and gram-negative bacilli. A concentration of 12.5 mug/ml inhibited 92% of isolates of Pseudomonas aeruginosa, 82% of Serratia marcescens, 73% of Escherichia coli, 61% of Klebsiella spp., and 42% of Enterobacter spp. Most Proteus spp. were extremely suscepti...

2014
Zaid Al-Attar Lee Faulkner John Farrell Paul Whitaker Daniel Peckham Kevin Park Dean Naisbitt

Background Piperacillin is a -lactam antibiotic that is frequently used to combat bacterial infections in patients with cystic fibrosis. However, its use is associated with a high incidence of delayed-type hypersensitivity reactions. Our previous studies have shown lymphocyte proliferative responses and cytokine secretion from PBMCs in approximately 75% of hypersensitive patients. In contrast, ...

2014
Mohammed Amali Andrew Sullivan John Farrell Xaoli Meng Roz Jenkins Paul Whitaker Daniel Peckham B Kevin Park Dean J Naisbitt

Cystic fibrosis is the most common autosomal recessive condition in Caucasians and recurrent infections lead to a plethora of complications. Repeated courses of high dose intravenous b-lactam antibiotics, such as piperacillin, are employed for the treatment of respiratory exacerbations. Unfortunately, delayed-type hypersensitivity reactions develop in between 26-50% of treated patients. We have...

Journal: :Antimicrobial agents and chemotherapy 2016
Kristen Nichols Eun Kyoung Chung Chad A Knoderer Lauren E Buenger Daniel P Healy Jennifer Dees Ashley S Crumby Michael B Kays

The study objective was to evaluate the population pharmacokinetics and pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in an intensive care unit. Seventy-two serum samples were collected at steady state from 12 patients who received piperacillin-tazobactam at 100/12.5 mg/kg of body weight every 8 h infused over 4 h. Population pharmacokinetic analyses wer...

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