1. Waltman, S. R., and Kaufman, H. E.: Use of hydrophilic contact lenses to increase ocular penetration of topical drugs, INVEST. OPHTHALMOL. 9: 250, 1970. 2. Kaufman, H. E., Uotila, M. H., Gasset, A. R., et al.: The medical uses of soft contact lenses, Tr. Am. Acad. Ophthalmol. Otolaryngol. 75: 361, 1971. 3. Podos, S. M., Becker, B., Asseff, C , et al.: Pilocarpine therapy with soft contact le...

OBJECTIVE To further characterize the capacity of lovastatin to prevent hippocampal neuronal loss after pilocarpine-induced status epilepticus (SE) METHOD: Adult male Wistar rats were divided into four groups: (A) control rats, received neither pilocarpine nor lovastatin (n=5); (B) control rats, received just lovastatin (n=5); (C) rats that received just pilocarpine (n=5); (D) rats that receive...

in this study, the effects of subcutaneous (sc) injection of pilocarpine (a cholinomimetic agent) and atropine (a muscarinic receptors antagonist) were investigated on a tonic model of orofacial pain in rats. the contribution of the endogenous analgesic opioid system was assessed using naloxone (an opioid receptors antagonist). tonic orofacial pain was induced by sc injection of a diluted forma...

The effect on accommodation of pilocarpine given intramuscularly was studied on two species of monkey (Cercopithecus aethiops and Macaca irus), six young individuals of each species. The results are given as dose-response curves; 0.2 mg. per kilogram of pilocarpine caused little change in refraction, generally less than 2 D., and 2.0 mg. per kilogravi caused a large change in refraction in both...

The morphology of the outflow apparatus in human eyes which had been treated topically with either 2 or 4% pilocarpine on 4 occasions at 6-hourly intervals before enucleation was compared with an untreated control series of eyes from patients in a similar age range. In the pilocarpine-treated group the scleral spur was pulled posteriorly and internally, so that the angle formed by the scleral s...

The use of hydrophilic soft contact lenses for dispensation of pilocarpine is described. The release rate of pilocarpine from three materials of different water content was estimated and from this the surface concentrations were calculated. It is estimated that PolyHEMA can after 15 hours provide a 1 per cent surface concentration of pilocarpine, whereas higher water content materials (70 and 8...

Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE). We report a novel method to establish SE based on continuous ventral hippocampal stimulation (5 epochs) followed by low dose pilocarpine (40 mg/kg) challenge. Motor limbic seizure...

The lithium-pilocarpine (Li-Pc) model of status epilepticus (SE) is most convenient and frequently used for pathophysiological management strategies in search new, safe effective therapeutic agents including the natural remedies SE. Oral administration cinnamon (CIN) curcumin (CUR) can reduce neuroinflammation which a common feature neurodegenerative disorders. Although many studies on CUR effe...