Understanding of the antiinflammatory actions of nonsteroidal drugs is incomplete, but these actions are believed to occur in the periphery, without any contribution from the central nervous system. Recent research on the antipyretic antiinflammatory neuropeptide alpha-melanocyte-stimulating hormone indicates that it can act centrally to inhibit peripheral inflammation; this raises the possibil...

Clausena excavata (Lour.), locally known as "Kemantu hitam," is a common plant in Malaysian folklore medicine. This study evaluated the antioxidant properties of the solvent extracts of C. excavata leaves and determined the acute toxicity of methanolic extract C. excavata (MECE) leaves in Sprague-Dawley rats. Harvested leaves were dried and subjected to solvent extraction using petroleum ether,...

A series of novel thiazole derivatives (A, A1, A2) were synthesized starting from 1-(3-methoxy phenyl) ethanone and thiourea. The compound (A) was obtained by heating 1-(3-methoxy phenyl) ethanone with thiourea in iodine. Compound (A) on treatment with 4-nitrobenzaldehyde afforded (Z)-4-(3-methoxyphenyl)-N-(4-nitrobenzylidene) thiazole-2-amine (A1). Acylation of compound (A) with 4-nitrobenzoyl...

Amalakayas Rasayana (AR) is a polyherbal formulation mentioned in Ayurveda to treat aging and age-associated diseases. Being an antiaging drug, AR may have antioxidants and free radical scavenging activity to minimize free radical-induced damage which is a key cause of aging. The methanolic extract of AR was evaluated in vitro for total phenolic and tannin content, free radical scavenging activ...

Topical application of picryl chloride (PCL), 1 the chemically reactive form of the tr initrophenyl (TNP) hapten, regularly induces a contact hypersensitivity reaction (CS) that is of the long-lived type (>3 wk) (1). However, when T N P is coupled to cells in vitro and these cells are used for immunizat ion, three different immunological outcomes m a y ensue depending on the route of administra...

BACKGROUND Vernonia cinerea (L.) Less is used in folk medicine as a remedy for various diseases. OBJECTIVES The present study reports antioxidant and antimicrobial activities of solvent fractions of Vernonia cinerea. METHODS The antioxidant properties of solvent fractions of V. cinerea were evaluated by determining radicals scavenging activity, total flavonoid and phenolic contents measured...

Gynura procumbens is known as one of the herbal medicinal plants found in Indonesia and has been used from time to time. It claimed have various efficacy such anti-hyperglycemic, anti-hypertension, anti-microbial, anti-cancer, antioxidant. Other studies mention that G. possessed high antioxidant compounds had a natural-based supplement. However, further on optimizing extraction process yet be r...

To clarify the role of Peyer's patches in oral tolerance induction, BALB/c mice were treated in utero with lymphotoxin beta-receptor Ig fusion protein to generate mice lacking Peyer's patches. When these Peyer's patch-null mice were fed 25 mg of ovalbumin (OVA) before systemic immunization, OVA-specific IgG Ab responses in serum and spleen were seen, in marked contrast to low responses in OVA-f...

Argemone mexicana (L.) has a role in the treatment of epileptic disorders in Indian traditional system of medicine. We studied its effect on induced status epilepticus (SE) and oxidative stress in rats. SE was induced in male albino rats by administration of pilocarpine (30 mg/kg, ip) 24 h after injection of lithium chloride (3 mEq/kg, ip). Different doses of the ethanol extract of A. mexicana ...

T cells able to mediate specific delayed type hypersensitivity (DH) in mice in response to the haptens azobenzenearsonate (ABA), oxazolone (OX), and picryl chloride have been grown in continuous cultures. They were tested for their ability to react with the hapten in vitro and to induce anti-idiotype antibody in syngeneic mice. Incubation in vitro with OX-glycine blocked the ability of an anti-...