Background: Leukocyte activation results in a rapid increase in adhesion to the extracellular matrix due to the activation of β1 integrin receptors. A role for phosphatidylinositol (PI) 3-kinase in integrin activation has been proposed, as activation of integrins by many receptors can be blocked by PI 3-kinase inhibitors. One receptor that regulates integrins is the CD28 surface antigen; here, ...

alpha 1 Proteinase inhibitor (PI) is the principle inhibitor of neutrophil elastase, an enzyme that degrades many components of the extracellular matrix. Expression and regulation of alpha 1 PI, therefore, affects the delicate balance of elastase and antielastase, which is critical to turnover of connective tissue during homeostasis, tissue injury, and repair. In this study we show that express...

During the late phase of HIV type 1 (HIV-1) replication, newly synthesized retroviral Gag proteins are targeted to the plasma membrane of most hematopoietic cell types, where they colocalize at lipid rafts and assemble into immature virions. Membrane binding is mediated by the matrix (MA) domain of Gag, a 132-residue polypeptide containing an N-terminal myristyl group that can adopt sequestered...

[Background:] The band structure of the negative-parity states $^{24}$Mg has not yet been clarified. $K^\pi=0^-$, $K^\pi=1^-$, and $K^\pi=3^-$ bands have suggested, but assignments inconsistent between experiments theories. [Purpose:] Negative-parity are investigated by microscopic reaction calculations via proton alpha inelastic scattering to clarify assignment for observed spectra. [Method:] ...

Pyrrole-imidazole (PI) polyamide is a novel gene regulating agent that competitively inhibits transcription factor binding to the promoter of the specific target gene. Liver fibrosis is an integral stage in the development of chronic liver disease, and transforming growth factor β (TGFβ) is known to play a central role in the progression of this entity. The aim of this study was to evaluate the...

Poster Presentation: American Association for Cancer Research: “Advances in Prostate Cancer Research”, San Diego, CA, January 21-24. AR-Enhanced α6β1 Integrin and Bcl-xL Expression Promotes Androgen-Independent Prostate Tumor Cell Survival Independently of PI-3K Signaling Laura E. Lamb , Jelani Zarif , and Cindy K. Miranti Laboratory of Integrin Signaling and Tumorigenesis, Van Andel Research I...

We study the interactions of systems two and three nondegenerate mesons composed pions kaons at maximal isospin using lattice QCD, specifically $\pi^+K^+$, $\pi^+\pi^+K^+$ $K^+K^+\pi^+$. Utilizing stochastic LapH method, we determine spectrum these on CLS $N_f=2+1$ ensembles with pion masses $200$ MeV $340$ MeV, include many levels in different momentum frames. constrain K matrices describing t...

We consider three-particle systems consisting of two identical particles and a third that is different, with all being spinless. Examples include $\pi^+\pi^+ K^+$ $K^+K^+\pi^+$. derive the formalism necessary to extract two- infinite-volume scattering amplitudes from spectrum such in finite volume. use relativistic based on an all-orders diagrammatic analysis generic effective field theory, ado...

In this work we study the doubly charmed baryon decays $\Xi_{cc}^{++}\to\Xi_c^{(\prime)+}\pi^+$ within framework of non-relativistic quark model (NRQM). Factorizable amplitudes are expressed in terms transition form factors, while nonfactorizable arising inner $W$-emission evaluated using current algebra and pole baryonic matrix elements axial-vector factors. Nonperturbative parameters then cal...