• Synthesis of a chromogenic analogue myo -inositol hexaphosphate. Amenable to g-scale. Docking experiments confirmed the compatibility with active site phytases. Phytases operate experimentally this fluorogenic substrate. A new pentakisphosphate was synthesized, which featured dansyl group at position C-5. The fluorescent tag removed from inositol by 6-atom spacer prevent detrimental steric in...

In anesthetized, paralyzed rats intravenous administration of the acetylcholinesterase inhibitor physostigmine (PHY) (100 micrograms/kg) evoked a dose-related rise in arterial pressure (AP) and heart rate (HR) and an associated increase in sympathetic nerve activity (SNA). The responses to PHY were blocked by electrolytic lesions of, or microinjection of kainic acid into, a specific site in the...

The test of the Standard Model through the measurements of Z to fermion couplings can bene t from much enhanced sensitivity by using longitudinally polarized electron beams. This report reviews preliminary electroweak measurements from SLD on heavy quark production at the Z, using 150,000 hadronic Z decays accumulated during the 93-95 runs with high electron beam polarization. The parity violat...

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Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR). We aimed (1) to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who manifested HSRs clinically; (2) to correlate LTA results with the clinical syndrome; (3) to correlate LTA results with the human leukocyte antigen (HLA...