Photodynamic Therapy of Tumors In article number 2205440, Zhiyang Liu, Quan Li, and co-workers exploit the hypoxic properties solid tumors to construct a hypoxia-responsive photosensitizer. When non-fluorescent photosensitizer enters tumors, it is reduced by overexpressed azoreductase generate fluorescent with aggregation-induced emission property, which can realize fluorescence-activatable ima...

the main goal in endodontic treatment is to eradicate or at least reduce intraradicular microbial population to levels that are more compatible with periapical lesions healing process. since endodontic infections are polymicrobial in nature, intraradicular survival of endodontic microbiota and their pathogenic properties are influenced by a combination of their virulence factors. the purpose of...

background and aims. considering the importance of disinfecting dentin after cavity preparation and the possible effect of disinfection methods on induction of various reactions between the tooth structure and the adhesive restorative material, the aim of the present study was to evaluate microleakage of composite resin restorations after disinfecting the prepared dentin surface with nd:yag and...

Introduction: Mitoxantrone (MX) has been introduced as a photosensitizer drug. However, due to some side effects, the widespread use of this drug has been confronted with some limitations. Hollow gold nanoshells (HGN) have attracted considerable attention due to their interesting photochemical features that can use as nanocarrier. In this paper, the thermal response of MX and the use of this pr...

Photodynamic Control-Mediated Holographic Composites In article number 2100363, Jae-Won Ka and co-workers propose new holographic composites with photodynamic control, composed of photosensitizers, singlet oxygen receptors, polymeric binders. Upon laser irradiation, photoexcited sensitizers generate oxygens, which can be detected by their receptors structural changes. Such changes within the co...

Phthalocyanines (Pcs) are a group of promising photosensitizers for use in photodynamic therapy (PDT). However, their extremely low solubility and their strong tendency to aggregate in aqueous solution greatly restrict their application. Conjugation of Pc macrocycles with peptide ligands could be a very useful strategy to optimize the physical properties of Pcs not only by increasing their wate...

36 LLE Review, Volume 77 Photodynamic therapy is a treatment in which the combination of a dye, light, and oxygen causes photochemically induced cell death. Observations of this effect occurred at least as early as the end of the last century. In 1900, Raab reported that the dye acridine rapidly killed paramecia when exposed to light, but had no effect in the dark.1 This observation quickly ins...

Cervical cancer is the fourth cause of cancer death in women. Curcumin has antineoplastic properties. Furthermore, curcumin may be used as a photosensitizing agent in Photodynamic Therapy. This study aimed to investigate the effects of Photodynamic Therapy in cellular viability using curcumin-nanoemulsion as a photosensitizing drug in cervical carcinoma cell lines. The empty nanoemulsion presen...

The combination of chemotherapy and photodynamic therapy has emerged as a promising strategy for cancer therapy due to its synergistic effects. In this work, PEGylated silver nanoparticles decorated with graphene quantum dots (Ag-GQDs) were tested as a platform to deliver a chemotherapy drug and a photosensitizer, simultaneously, in chemo-photodynamic therapy against HeLa and DU145 cancer cells...