Photobacterium damselae subsp. piscicida (formerly Pasteurella piscicida) is the causative agent of pasteurellosis or pseudotuberculosis in warm water marine fish. Enzymes which neutralize reactive oxygen species, produced during aerobic metabolism or during respiratory burst in fish macrophages, are important virulence factors in many pathogens. This study characterizes a periplasmic superoxid...

Bacterial diseases of marine fish inflict significant economic damage to fisheries and aquaculture pose an increasing risk public health. When addressing disease, accumulating body research suggests adding another factor the classic epidemiological triangle host-environment-pathogen: microbiome. The gills, being a gateway into bearing important role in homeostasis, have been found be proxy gut ...

Redbanded seabream, Pagrus auriga Valenciennes (Sparidae), has a wide geographical distribution and a very important commercial value in European countries. Recently, this species has been successfully cultured in the C.I.F.P.A. El Toruño (El Puerto de Santa Maria, Cadiz, Spain) as a result of extensive studies on its reproductive cycle, nutrition and growth (Prieto, Cañavate & Cardenas 2003). ...

Photobacterium damselae subsp damselae (Pdd) is a Vibrionaceae that has a wide pathogenic potential against many marine animals and also against humans. Some strains of this bacterium acquire iron through the siderophore vibrioferrin. However, there are virulent strains that do not produce vibrioferrin, but they still give a strong positive reaction in the CAS test for siderophore production. I...

Aquaculture is the fastest growing food-producing sector, accounting almost 50% of the world food fish demand. Considering the projected population growth over the next two decades, it is estimated that at least an additional 40 million tonnes of aquatic food will be required by 2030 to maintain the current per capita consumption (NACA/FAO, 2001). Marine aquaculture production was 30.2 million ...

Membrane repair emerges as an innate defense protecting target cells against bacterial pore-forming toxins. Here, we report the first paradigm of Ca2+-dependent repair following attack by a small β-pore-forming toxin, namely, plasmid-encoded phobalysin of Photobacterium damselae subsp. damselae In striking contrast, Vibrio cholerae cytolysin, the closest ortholog of phobalysin, subverted repair...

Photobacterium damselae subsp. piscicida (Phdp) is a Gram-negative pathogen agent of an important fish septicemia. The key virulence factor of Phdp is the plasmid-encoded exotoxin AIP56, which is secreted by exponentially growing pathogenic strains. AIP56 has 520 amino acids including an N-terminal cleavable signal peptide of 23 amino acid residues, two cysteine residues and a zinc-binding regi...

Photobacterium damselae subsp. piscicida is the causative agent of fish pasteurellosis, a severe disease affecting cultured marine fish worldwide. In this study, suppression subtractive hybridization was used to identify DNA fragments present in the virulent strain PC554.2, but absent in the avirulent strain EPOY 8803-II. Twenty-one genomic regions of this type (that included twenty-six distinc...