The antiphospholipid syndrome (APS) is defined by the association of arterial and/or venous thrombosis and/or pregnancy complications with the presence of at least one among the main antiphospholipid antibodies (aPL) (i. e., Lupus anticoagulants, LA, IgG and/ or IgM anticardiolipin antibodies, aCL, IgG and/or IgM antiβ2-glycoprotein I antibodies, aβ2-GPI). Several clinical studies have consiste...

The aim of the present study was to find a way of prepare silybin-phospholipid complex to make oral bioavailability of silybin increase and to study its physicochemical properties and to compare the pharmacokinetic characteristics and bioavailability after oral administration of silybin-phospholipid complex and silybin-N-methylglucamine in rats. Using ethanol as a reaction medium, silybin and p...

Mushroom (Agaricus blazei Murill) extract has been reported to possess antitumor effects through immune activation. Here, we investigated the beneficial effects of combining A. blazei extract with marine phospholipids in comparison to A. blazei extract alone on myeloma sp2 tumor suppression when orally administrated. The experimental groups designed for sp2 tumor bearing BALB/c nu/nu mice were ...

Oosting et al's' recent report on various phospholipid/protein antigen complexes (involving prothrombin, protein S, or protein C) recognized by antiphospholipid antibodies (aPL) has set the stage for other aPL investigators to redefine and evaluate the binding specificity of aPL. The nature of the neoepitopes induced by protein/phospholipid interactions is still unresolved. Firstly, the antigen...

Ten years ago, describing what is new in phospholipid signaling in ten pages of Cell would have been easy; it would have been essentially a summary of the phosphoinositidase C (PIC) story: phosphatidylinositol(4,5)bisphosphate (Ptdlns(4,5)P2) hydrolysis to inositiol(1,4,5)trisphosphate (Ins(1",4,5)P3), with the synergistic action of Ca 2÷ (mobilized by Ins(1,4,5)P3) and diacylglycerol (DAG) on ...

background and objectives: phospholipases are a group of enzymes that breakdown phospholipid molecules producing second products. these second products play a diverse role in the cell such as signal transduction and digestion in humans. in this study, the effect of phospholipids on the expression of pld genes of a. fumigatus was investigated. the pld genes of this fungus were also investigated ...

We hypothesized that lower proportion of serum phospholipid docosahexaenoic acid (DHA) is inversely associated with increased cardiovascular risk and vascular function in metabolically healthy men. To elucidate it, we first compared serum phospholipid free fatty acid (FA) compositions and cardiovascular risk parameters between healthy men (n = 499) and male patients with coronary artery disease...

Phospholipids and hyaluronan are two key biomolecules that contribute to the excellent lubrication of articular joints. alone in combination with have also displayed low friction forces on smooth surfaces micro- nanosized tribological contacts. In an effort develop aqueous-based systems, it is highly relevant explore if these types molecules able provide efficient macroscopic contacts involving...