Studies were conducted to compare the phosphate-binding efficacy of lanthanum carbonate directly with other clinically used phosphate binders and to evaluate any potential adverse pharmacology. To examine the phosphate-binding efficacy, rats with normal renal function and chronic renal failure received lanthanum carbonate, aluminum hydroxide, calcium carbonate, or sevelamer hydrochloride in sev...

Tenapanor (RDX5791, AZD1722), a first-in-class small molecule with minimal systemic availability, is an inhibitor of the sodium/hydrogen exchanger isoform 3. Tenapanor acts locally in the gut, where it reduces absorption of sodium and phosphate. It is being studied in patients with chronic kidney disease requiring dialysis, who are often administered phosphate binders such as sevelamer to help ...

End-stage renal disease impairs functional status, diminishes quality of life and shortens lifespan. Despite recent improvements in survival of affected individuals in the USA, 50% of patients will die within 3 years of initiating hemodialysis [1]. Nephrologists, dialysis clinic providers, insurers and patients are all in need of therapeutic advances that can further impact mortality in this po...

The effectiveness of phosphate binders can be assessed by evaluating urinary phosphorus excretion in healthy volunteers, which indicates the ability of the phosphate binder to reduce gastrointestinal phosphate absorption. Healthy volunteers were enrolled into one of five separate randomized trials; four were open label and one double blind. Following a screening period of ≤28 days, participants...

      The aim of this research is to assess the impact of clinical pharmacist-provided education on medication adherence in haemodialysis patients. Ninety haemodialysis patients were randomized into two groups. Brief medication questionnaire (BMQ), a tool for screening adherence was administered to both groups at the baseline to assess adherence to antihypertensives, vitamin D analogues, phosph...

INTRODUCTION Adequate dietary phosphorus intake and the use of phosphorus binders are the main tools for treating hyperphosphatemia. Thus, its success depends essentially on the patient's ability to understand and adhere to the dietary plan and the use of phosphate binders. OBJECTIVE To evaluate hyperphosphatemic patients adherence and knowledge about phosphate control treatment. METHODS Th...

BACKGROUND Ferric citrate (FC) is a phosphate binder in development for the treatment of hyperphosphatemia in patients with end-stage renal disease (ESRD). In clinical trials, FC improved patient serum phosphorus levels and increased serum ferritin and percent transferrin saturation. Because nephrologists respond to increases in these iron measures by reducing intravenous (IV) iron and erythrop...

Silica refractory bricks are used especially in the metallurgical industries, due to desirable properties such as particularly their high melting point and their rigidity and strength at high temperatures. In this research, different amount of SiC were added to Silica refractory containing different binders such as Borax, Boric acid, Calcium nitride, Sodium tri poly phosphate, Sodium hexametaph...