Migraine is a common neurological disorder and is characterized by debilitating head pain and an assortment of additional symptoms which can include nausea, emesis, photophobia, phonophobia, and occasionally, visual sensory disturbances. A number of genes have been implicated in the pathogenesis of this disease, including genes involved in regulating the vascular system. Of particular importanc...

Antonios Kerasnoudis, MD Ralf Gold, MD Min-Suk Yoon, MD SECTION 1 A 48-year-old woman was admitted to our department with recurrent episodes of throbbing right parietal headache lasting for hours. The patient was afebrile and neurologic examination disclosed no signs of meningeal irritation or papilledema. Blood pressure (BP) levels and heart rate were normal ( 140/90 mm Hg, 70 bpm) on repeat m...

A 19-year-old woman presented with a five month history of headaches. Initially the headaches had been intermittent. For the two months prior to presentation the patient had a constant headache. There was no precipitant at onset. The headache was improved by recumbancy. It was associated with daily vomiting resulting in a 20 pound weight loss but no photophobia or phonophobia. The neurological ...

BACKGROUND Many women with migraine experience a change in migraine frequency associated with the menstrual cycle. This study was undertaken to study the effect of vitamin E as a prophylactic agent on women with menstrual migraine. MATERIAL/METHOD During a placebo-controlled double-blinded trial, 72 women with menstrual migraine received placebo (identical in appearance to vitamin E) daily fo...

BACKGROUND Hyperacusis and phonophobia are common, debilitating symptoms in Williams syndrome (WS), yet little is known about their underlying audiologic and neurologic processes. METHODS The mothers of 49 subjects with WS were asked to complete the Hyperacusis Screening Questionnaire. Subjects with reported hyperacusis and sufficient developmental capacity underwent comprehensive audiologica...

CLINICAL HISTORY A 38-year-old woman reported a history of headache since aged 11 years, occurring about once a month. Triggers included stress and missing a meal, and she described a severe left or right hemicranial throbbing pain with associated nausea, vomiting, photophobia, and phonophobia, but no aura. Attacks lasted up to 3 days. An acetaminophen/aspirin/caffeine combination “dulled” the ...

BACKGROUND During migraine attacks, patients generally have photophobia and phonophobia and seek for environments with less sensorial stimulation. Present work aimed to quantify cortical partial directed coherence (PDC) of electroencephalographic (EEG) recordings from migraine patients and controls in occipital, parietal, and frontal areas with or without photic stimulation. Our hypothesis is t...

OBJECTIVE To determine whether baseline nausea or prior triptan treatment for migraine impact the effectiveness of diclofenac potassium for oral solution in treating acute migraine. BACKGROUND A great deal of variability exists in patients' response to migraine medications. Migraine-associated nausea is common and debilitating and can reduce the effectiveness of oral medications. It may cause...

Migraine is amongst the oldest of diseases known to mankind. Migraine is a heterogenous entity, usually characterised by periodic attacks of headache on one or both sides of the head. These may be accompanied by nausea, vomiting, increased sensitivity of the eyes to light (photophobia), increased sensitivity to sound (phonophobia), dizziness, blurred vision, cognitive disturbances, and other sy...

PURPOSE To study the audiovestibular functions in cases of migraine with or without vertigo. MATERIALS AND METHODS This was a prospective study involving 50 cases of migraine who were divided into 2 groups: patients with vertigo and those without. All patients underwent a detailed otological and neurootological examination followed by full audiological and vestibular investigation including p...