نتایج جستجو برای: phenylpyrrolidine 25 dione

تعداد نتایج: 359816  

Journal: :Chemical & pharmaceutical bulletin 2009
David Dako Chiozem Hanh Trinh-Van-Dufat Jean Duplex Wansi Céline Mbazoa Djama Véronique Simone Fannang Elisabeth Seguin François Tillequin Jean Wandji

Two new friedelane-type triterpenes named 12alpha-hydroxyfriedelane-3,15-dione and 3beta-hydroxyfriedelan-25-al, together with six known compounds were isolated from the stems of Drypetes paxii Hutch. (Euphorbiaceae). Their structures were established on the basis of conventional 1 dimensional (1D) NMR methods, 2D shift-correlated NMR experiments and mass spectra. The five friedelane-type trite...

Mycobacterium smegmatis PTCC 1307 (CIP 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. The side chain of cholesterol, as the substrate, was selectively cleaved in the presence of five enzyme inhibitors. An intermediate structure with intact side chain, cholest-4-ene-3-one, ...

2009
Katarzyna Mitka Piotr Kowalski Dariusz Pawelec Zbigniew Majka

2-Substituted derivatives of indane-1,3-dione 3a–f , 5a–g, 6a–g were synthesized and investigated as anticoagulant agents. 2-Arylindane-1,3-diones (3) were obtained in the reaction of phthalide with appropriate arylaldehydes. 2-Arylmethyleneindane-1,3-diones (5) were prepared by condensation of indane-1,3-dione with the corresponding arylaldehydes. The compounds 5 were converted into their meth...

2011
Danylo Kaminskyy Dmytro Khyluk Olexandr Vasylenko Lucjusz Zaprutko Roman Lesyk

The synthesis and evaluation of the anticancer activity of 3'-aryl-5'-arylidene-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-diones and spiro[3H-indole-3,2'-thi-azolidine]-2,4'(1H)-dione-3'-alkanoic acid esters were described. The structure of the compounds was determined by (1)H and (13)C NMR and their in vitro anticancer activity was tested in the National Cancer Institute. Among the tested co...

2013
N. Sureshbabu V. Sughanya

In the title compound, C21H23N3O7, the pyrimidine-dione ring adopts a screw-boat conformation, whereas the cyclo-hexenone ring adopts an envelope conformation, with the C atom bearing the methyl groups as the flap atom. The dihedral angle between the mean planes of the pyrimidine-dione and cyclo-hexenone rings is 58.78 (2)°. The pyrimidine-dione and cyclo-hexenone rings form dihedral angles of ...

Journal: :Journal of natural products 2008
Shu-Hua Qi Si Zhang Hui Huang

Four new purine alkaloids, namely, 6-(1'-purine-6',8'-dionyl)suberosanone ( 1), 3,9-(2-imino-1-methyl-4-imidazolidinone-5-yl)isopropenylpurine-6,8-dione ( 2), 1-(3'-carbonylbutyl)purine-6,8-dione ( 3), and 9-(3'-carbonylbutyl)purine-6,8-dione ( 4), together with three known compounds, guanosine ( 5), thymidine ( 6), and adenosine ( 7), were isolated from the EtOH/CH 2Cl 2 extracts of the South ...

2015
Yuriy M. Kononevich Ludmila S. Bobkova Alexander S. Smolski Anatoly M. Demchenko

New 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione have been synthesized by the reaction of 3-cyclohexyl-7-thio-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione with alkylhalogenides. The synthesized compounds were tested for antioxidant activity on the model of Fe(2+)-dependent oxidation of adrenaline in vitro. It was found that the antiradical activity of...

Journal: :Acta poloniae pharmaceutica 2014
Agnieszka Zagórska Anna Czopek Karolina Pełka Krystyna Stanisz-Wallis Maciej Pawłowski

The chromatographic parameters of arylpiperazinylpropyl derivatives of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione were investigated using reversed-phase thin layer chromatography method. The results revealed that R(M0) of investigated compounds depended on substituent in arylpiperazinyl fragment as well as on a nature of (cycloalkyl)aromatic ring at 5 position of imidazolidine-2...

Journal: :E3S web of conferences 2023

The rate constants of the Diels-Alder reaction 9,10-dimethylanthracene with tetracyanoethylene, 4-phenyl-1,2,4-triazoline-3,5-dione, maleic anhydride, and N-phenylmaleimide in solution have been determined. It was found that tetracyanoethylene 4-phenyl-1,2,4-triazoline-3,5-dione can react instantly 9,10-dimethylanthracene, which is a representative toxic polycyclic aromatic hydrocarbons. kineti...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید