The title compound, C(2)H(10)N(2) (2+)·2C(10)H(9)N(2)O(-), is composed of deprotonated 5-methyl-2-phenyl-1H-pyrazol-3(2H)-one anions (PMP(-)) and protonated ethyl-enediamine cations (H(2)en(2+)). The ethyl-enediammonium ion is located on a crystallographic inversion center. The dihedral angle between the phenyl and pyrazole rings is 39.73 (8)°. The two components are connected through N-H⋯O and...

Single crystals of the title compound, C(10)H(13)OS(+)·Br(-), were obtained from ethyl acetate/ethyl ether after reaction of acetophenone with hydro-bromic acid and dimethyl-sulfoxide. The carbonyl group is almost coplanar with the neighbouring phenyl ring [O-C-C-C = 178.9 (2)°]. The sulfanium group shows a trigonal-pyramidal geometry at the S atom. The crystal structure is stabil-ized by C-H⋯B...

The novel racemic secondary alcohol (±)-2-{[4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenyl-1-ethanol (12) has been successfully synthesized through S-alkylation of 4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazole-3-thiol (10) in alkaline medium with 2-bromo-1-phenylethanone followed by reduction the corresponding ketone 11. All compounds were characterized IR, 1D (1H, 13C, DEPT...

We report herein the synthesis of substituted 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthylen-1(2H)-one from the reactions of 4-[4-(chloromethyl)phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl ...

Reactions of 2-X-2-(Y-phenyl)-l,3-indandiones (X = C1, Br; Y = H, p-N02, /?-CH30, m-CH30) with anions of acetylacetone, ethyl malonate nitromethane, and 2-nitropropane were carried out. It was found that the starting indandione was converted during the reaction into the anion of 2-(Y-phenyl)-l,3-indandione (/) and bis-2-(Y-phenyl)-l,3-indandione (II). The ratio of the products / and II was depe...

Ethyl alcohol is produced in the United States by two major procedures, fermentation and chemical synthesis. Practically all current industrial ethyl alcohol is manufactured synthetically from petroleum and natural gas. All beverage alcohol is produced through the fermentation of cereal grains, molasses. and other materials with high starch and sugar content. Chemically, both alcohols are essen...

Alcoholism is a complex disorder that, in man, appears to be genetically influenced, although the underlying genes and molecular pathways are not completely known. Here the intragastric alcohol feeding model in rodents was used together with high mass accuracy LC/MS analysis to assess the metabonomic changes in non-polar metabolite profiles for livers from control and alcohol treated rats and m...

A mast cell protease has been purified over 260-fold from rat thyroid homogenates. The purified enzyme hydrolyzes denatured thyroglobulin, denatured hemoglobin, and fibrinogen. It also rapidly hydrolyzes the ester substrates, benzoyltyrosine ethyl ester, benzoylphenylalanine ethyl ester, and acetyltyrosine ethyl ester. The pH optimum for thyroglobulin and benzoyltyrosine ethyl ester hydrolysis ...

AIMS This study examined the possibility of using hair samples other than scalp hair for analysis of fatty acid ethyl esters (FAEE) as markers for alcohol misuse. METHODS Samples of scalp and pubic hair and, if available, axillary, beard and body hair of one teetotaller, five moderate social drinkers and 22 fatalities were analysed for FAEE by head-space solid-phase microextraction and gas ch...