phenformin

Alessandro Protti Riccarda Russo Paola Tagliabue Sarah Vecchio Mervyn Singer Alain Rudiger Giuseppe Foti Anna Rossi Giovanni Mistraletti Luciano Gattinoni

INTRODUCTION Lactic acidosis can develop during biguanide (metformin and phenformin) intoxication, possibly as a consequence of mitochondrial dysfunction. To verify this hypothesis, we investigated whether body oxygen consumption (VO2), that primarily depends on mitochondrial respiration, is depressed in patients with biguanide intoxication. METHODS Multicentre retrospective analysis of data ...

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Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells

2018

Melissa Hodeib Martin P. Ogrodzinski Laurent Vergnes Karen Reue Beth Y. Karlan Sophia Y. Lunt Paul-Joseph P. Aspuria

Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC). Studies describing the mechanisms by which metformin affects HGSC are ongoing, but detailed analysis of its effect on the cellular metabolism of both HGSC cells and their precursor, ...

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Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity

2017

Magdalena Markowicz-Piasecka Joanna Sikora Łukasz Mateusiak Elżbieta Mikiciuk-Olasik Kristiina M Huttunen

The results of epidemiological and pathophysiological studies suggest that type 2 diabetes mellitus (T2DM) may predispose to Alzheimer's disease (AD). The two conditions present similar glucose levels, insulin resistance, and biochemical etiologies such as inflammation and oxidative stress. The diabetic state also contributes to increased acetylcholinesterase (AChE) activity, which is one of th...

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Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

2015

Sara Granja Ibtissam Marchiq Renaud Le Floch Conceição Souto Moura Fátima Baltazar Jacques Pouysségur

Most cancers rely on aerobic glycolysis to generate energy and metabolic intermediates. To maintain a high glycolytic rate, cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters (MCT1/4). These transporters require a chaperone, CD147/BASIGIN (BSG) for trafficking to the plasma membrane and function.To validate the key role of these transporters in lun...

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نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید

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