Tissue engineering is defined as the designing and engineering of structures to rebuild and repair a body damaged tissue. Scaffolding Poly Hydroxy Butyrate Valraty (PHBV) has shown good biocompatibility and biodegradable properties. Nanofibers have improved the performance of biomaterials, and could be considered effective. One of the important methods for designing nanofiber scaffold is the el...

The combination of biopolymers and bioactive inorganic particles for bone tissue regeneration has been investigated in the last decades. However, several studies report discordant results on specific synergistic effect compounds. A comparative study porous scaffolds obtained by most promising is herein reported. Specifically, have fabricated Thermally Induced Phase Separation method using poly(...

Nerve conduits containing highly aligned architecture that mimics native tissues are essential for efficient regeneration of nerve injuries. In this study, a biodegradable nerve conduit was constructed by converting a porous micropatterned film (PHBV-P(L-D,L)LA-PLGA) into a tube wrapping aligned electrospun fibers (PHBV-PLGA). The polymers were chosen so that the protective tube would erode slo...

Degradabilities of four kinds of commercial biodegradable plastics (BPs), polyhydroxybutyrate and hydroxyvalerate (PHBV) plastic, polycaprolactone plastic (PCL), blend of starch and polyvinyl alcohol (SPVA) plastic and cellulose acetate (CA) plastic were investigated in waste landfill model reactors that were operated as anaerobically and aerobically. The application of forced aeration to the l...

BACKGROUND With the thrombogenic tendency and permanent implant nature of metallic stents, synthetic polymers have been proposed as candidate materials for stents and local drug delivery designs. We investigated the biocompatibility of several synthetic polymers after experimental placement in the coronary artery. METHODS AND RESULTS Five different biodegradable polymers (polyglycolic acid/po...

Microparticles of poly(ε-caprolactone) (PCL) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) containing manidipine dihydrochloride (MAN) were successfully prepared by the simple emulsion/solvent evaporation method. All formulations showed loading efficiency rates greater than 80% and average particle size less than 8 μm. Formulations had spherical shape with smooth and porous surface fo...

The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 microm were obtained. The effect of CO(2) and liquid flow, temperature and pressure on particle...