Electron transfer within rat neuronal nitric-oxide synthase (nNOS) was investigated by pulse radiolysis. Radiolytically generated 1-methyl-3-carbamoyl pyridinium (MCP) radical was found to react predominantly with the heme of the enzyme with a second-order rate constant for heme reduction of 3 x 10(8) m(-1) s(-1). In the calmodulin (CaM)-bound enzyme a subsequent first-order phase was observed ...

Abstract A new multi-site phase-transfer catalyst (MPTC), viz., N,N’-dioctyl-4,4’-bipyridium dibromide containing bi-site was prepared and proved by FT-IR, 1H NMR, 13C NMR, mass and elemental analysis. The enhancement of C-N+ peak intensity at 1179 cm−1 noticed in FT-IR, the agreement of m/z values, viz., 542.43 bi-site respectively with their theoretical values and the percentage of C, H, N e...

The second-order rate constants for reaction of the Mg2+ complexes of phosphorylated pyridine monoanions with Mg(OH)+ a re 104-106-fold larger than the second-order rate constants for their reaction with water (25 OC, ionic strength 1.5). Of the 106-fold rate enhancement with the phosphorylated 4morpholinopyridine/Mg2 complex, 1 04-fold is attributed to the greater nucleophilicity of Mg(OH)+ co...

the cycloaddition reaction of diphenylnitrilimine on the 1,5-benzodiazepines has been studied. new molecules of triazolobenzodiazepines type have been isolated and characterized.