BACKGROUND Patients with severe apnoea may have an impaired pharyngeal dilating reflex related to decreased pharyngeal sensitivity. The accuracy of a simple new procedure to measure pharyngeal sensitivity and to diagnose sleep disordered breathing (SDB) was investigated. METHODS Pharyngeal disappearance and appearance sensory perception thresholds were measured by delivering different airflow...

OBJECTIVE To examine the characteristics and changes in the pharyngeal phase of swallowing according to fluid viscosity in normal healthy persons, to help determine fluid intake methods in more detail than the use of standardized fluid. METHODS This was a prospective observational study involving 10 normal healthy adults. While the participants sequentially took in fluids with 10 different vi...

Background: Patients with severe apnoea may have an impaired pharyngeal dilating reflex related to decreased pharyngeal sensitivity. The accuracy of a simple new procedure to measure pharyngeal sensitivity and to diagnose sleep disordered breathing (SDB) was investigated. Methods: Pharyngeal disappearance and appearance sensory perception thresholds were measured by delivering different airflow...

Fibroblast growth factor (Fgf) proteins are important regulators of pharyngeal arch development. Analyses of Fgf8 function in chick and mouse and Fgf3 function in zebrafish have demonstrated a role for Fgfs in the differentiation and survival of postmigratory neural crest cells (NCC) that give rise to the pharyngeal skeleton. Here we describe, in zebrafish, an earlier, essential function for Fg...

OBJECTIVE To evaluate the effect of alcohol cessation on the risk of developing laryngeal and pharyngeal cancers, combining available evidence in the scientific literature in a meta-analysis. METHODS A systematic literature review was conducted, and a meta-analysis was applied on the retrieved studies. The generalised least squares method was used to estimate the trend from dose-response data...

OBJECTIVE This study aimed to identify factors related to outcomes of the pharyngeal foreign bodies in children and to improve the management protocol of this disease. METHODS The medical records of 131 children with pharyngeal foreign bodies hospitalized in the hospital were retrospectively reviewed. RESULTS Significant differences were observed between the two groups (dislodgement and rem...

To better understand pharyngeal airway mechanics as it relates to the pathogenesis and treatment of obstructive sleep apnoea, we have developed a novel application of magnetic resonance imaging (MRI) with non-invasive tissue tagging to measure pharyngeal wall tissue motion during active dilatation of the airway. Eleven anaesthetized Sprague-Dawley rats were surgically prepared with platinum ele...

In this issue of Blood, Diomede and colleagues establish a novel Caenorhabditis elegans model of primary amyloid cardiotoxicity. Using pharyngeal pumping as a surrogate for cardiac function, they find that human amyloidogenic light-chain proteins directly impair pharyngeal activity. Direct toxicity was associated with the release of reactive oxygen species, and pharyngeal activity was restored ...

Before a bolus is pushed into the pharynx, oral sensory processing is critical for planning movements of the subsequent pharyngeal swallow, including hyoid bone and laryngeal (hyo-laryngeal) kinematics. However, oral and pharyngeal sensory processing for hyo-laryngeal kinematics is not fully understood. In 11 healthy adults, we examined changes in kinematics with sensory adaptation, sensitivity...