This article establishes the pharmacokinetic-pharmacodynamic parameters that are important when considering the intracellular activity of antibiotics. Generally speaking, the main classes of antibiotics seem to share globally the same properties against extracellular and intracellular organisms. The specific cellular pharmacokinetic properties may modulate those parameters so as to let other on...

Hydroxycinnamic acids are the most widely distributed phenolic acids in plants. Broadly speaking, they can be defined as compounds derived from cinnamic acid. They are present at high concentrations in many food products, including fruits, vegetables, tea, cocoa, and wine. A diet rich in hydroxycinnamic acids is thought to be associated with beneficial health effects such as a reduced risk of c...

........................................................................ 2 INTRODUCTION.................................................................. 3 PHARMACODYNAMIC PROPERTIES................................ 4 PHARMACOKINETIC PROPERTIES .................................. 5 (A) ABSORPTION AND DISTRIBUTION.......................................... 5 (B) METABOLISM AND ELIMINATION ............

The data in this article outline the methods used for the administration of GET 73 in the first time-in-human manuscript entitled "Phase I randomized clinical trial for the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy male volunteers" (Haass-Koffler et al., 2017) [1]. Data sets are provide...

Biodistribution of nanoparticles is dependent on their physicochemical properties (such as size, surface charge, and surface hydrophilicity). Clear and systematic understanding of nanoparticle properties' effects on their in vivo performance is of fundamental significance in nanoparticle design, development and optimization for medical applications, and toxicity evaluation. In the present study...

BACKGROUND The pharmacokinetic basis of magnesium sulphate (MgSO4 ) dosing regimens for eclampsia prophylaxis and treatment is not clearly established. OBJECTIVES To review available data on clinical pharmacokinetic properties of MgSO4 when used for women with pre-eclampsia and/or eclampsia. SEARCH STRATEGY MEDLINE, EMBASE, CINAHL, POPLINE, Global Health Library and reference lists of eligi...

severe sepsis and septic shock are major problems as the result of high rates morbidity andmortality in intensive care units (icus). in the presence of septic shock, each hour of delay inthe administration of effective antibiotics is associated with a measurable increase in mortality.aminoglycosides are effective broad-spectrum antibiotics that are commonly used in icus forthe treatment of life...