N-Heterocyclic carbene-catalyzed reaction of 2-aroylvinylcinnamaldehydes with 2-aroylvinylchalcones proceeded via a triple Michael addition and intramolecular lactonization cascade to produce novel 9-(2-aroyl-3-aroylmethyl-1-indanyl)-3-arylindeno[2,1-c]pyran-1-ones in good yields with high diastereoselectivity. This reaction constructed six contiguous stereogenic centers in a single reactive ev...

After the landmark, IAEA trial confirming the potential of intra-arterially used Re 188 Lipoidol for the treatment of inoperable hepatocellular carcinoma (HCC), it was surprising to note that none of the participating centers took this work forward. To a nonnuclear physician or scientist, it would seem baffling, but we in NM are well aware of the difficulties in instituting a new radionuclide t...

The strategic goal of academic translational research is to accelerate translational science through the improvement and development of resources for moving discoveries across translational barriers through 'first in humans' studies. To achieve this goal, access to drug discovery resources and preclinical IND-enabling infrastructure is crucial. One potential approach of research institutions fo...

BACKGROUND The health status of the East Timorese population is very poor and much of the health system was destroyed during the violence of 1999. As in other developing countries, the lack of appropriate and high quality medicines significantly compromises patient care throughout the health system. The aim of this study was to examine the purchase, distribution and supply of pharmaceuticals in...

BACKGROUND Antibiotics use in in children are different from adults due to a lack of data on pharmacokinetics, pharmacodynamics, efficacy and safety of drugs, different physiological spectrum, pediatrics populations being vulnerable to the majority of the illnesses, and the adverse effect of their irrational use is more serious. However, antibiotic use is not explored much in a paediatric popul...

Cigarette smoking is the most avoidable cause of death in the United States, and although most smokers want to quit, initial attempts usually fail (Centers for Disease Control and Prevention, 2005a, 2005b). Smoking-related illnesses (e.g., cancer, cardiovascular disease) can be reduced by removing the risk factor. A multifaceted approach that includes a tobacco assessment to provide behavioral,...

Abstract Background and scope: The current situation in Iran suggests a good basis for advancement in biotechnology industries because the patents for many hi-tech medicines registered in developed countries are ending. Biosimilar and technology-oriented companies without patents will have the opportunity to enter the biosimilar market and move toward innovative initiatives. The present researc...

Abstract Background and scope: The current situation in Iran suggests a good basis for advancement in biotechnology industries because the patents for many hi-tech medicines registered in developed countries are ending. Biosimilar and technology-oriented companies without patents will have the opportunity to enter the biosimilar market and move toward innovative initiatives. The present researc...

In this paper, a bi-objective pharmaceutical supply chain network under uncertainty demand and transportation costs is modeled and developed. To control the uncertainty parameters, the robust optimization method is considering. The main objective of this paper determines the number and location of potential facilities such as drug manufacture centers and drug distribution centers by considering...

  Background: Poisoning is one of the main causes of visits to emergency departments and hospitals in Iran. Drug and Poison Information Centers (DPIC) are reliable sources to guide poisoned patients and provide information about pharmaceutical agents. This study was designed to analyze recorded phone calls to Iran DPICs during 2011-2012. Methods: This was a retrospective study on phone calls to...