نتایج جستجو برای: pharmaceutic adjuvants
تعداد نتایج: 6128 فیلتر نتایج به سال:
Commercial formulations of pesticides are invariably not single ingredients. Instead they are cocktails of chemicals, composed of a designated pesticidal "active principle" and "other ingredients," with the latter collectively also known as "adjuvants." These include surfactants, antifoaming agents, dyes, etc. Some adjuvants are added to influence the absorption and stability of the active prin...
A better understanding of the mechanisms of action of human adjuvants could inform a rational development of next generation vaccines for human use. Here, we exploited a genome wide transcriptomics analysis combined with a systems biology approach to determine the molecular signatures induced by four clinically tested vaccine adjuvants, namely CAF01, IC31, GLA-SE and Alum in mice. We report sig...
Adjuvant compounds are usually included in vaccinations in order to bolster total vaccine-specific responses or to tailor an immune response toward a desired endpoint, such as the production of gamma interferon or an increase in antibody titers. While most adjuvants are studied in regard to their impact on vaccine-specific responses during and just after the vaccination period, a detailed analy...
An effective protein-based vaccine for tuberculosis will require a safe and effective adjuvant. There are few adjuvants in approved human vaccines, including alum and the oil-in-water-based emulsions MF59 (Novartis Vaccines and Diagnostics), AS03 and AS04 (GlaxoSmithKline Biologics), AF03 (Sanofi), and liposomes (Crucell). When used with pure, defined proteins, both alum and emulsion adjuvants ...
The characteristic modulating effects of bacterial membrane adjuvants on the IgG subclass responses to lipopolysaccharide (LPS) were further investigated. Previous studies indicated that more hydrophobic adjuvants preferentially augmented the number of LPS-specific IgG1 plaque-forming cells (PFC) whereas more hydrophilic adjuvants induced predominantly IgG2 PFC, and that complex formation betwe...
Sub-cutaneous immunotherapy is an effective treatment for allergy. It works by helping to modify or re-balance an individual's immune response to allergens and its efficacy is greatly improved by the use of adjuvants, most commonly, aluminium hydroxide. Aluminium salts have been used in allergy therapy for many decades and are assumed to be safe with few established side-effects. This assumptio...
according to the vital role of pharmaceutical industry in health care system, pharmaceutical supply chain security, standard production and distribution of the pharmaceutical products are of great importance for pharmaceutical companies. therefore, applying technology, especially radio frequency identification (rfid), is essential to achieve these goals. moreover, due to the importance of secur...
Adjuvants are compounds incorporated into vaccines to enhance immunogenicity and the development of these molecules has become an expanding field of research in the last decades. Adding an adjuvant to a vaccine antigen leads to several advantages, including dose sparing and the induction of a more rapid, broader and strong immune response. Several of these molecules have been approved, includin...
Vaccines that protect against intracellular infections such as malaria, Leishmania and Chlamydia require strong cellular responses based on CD4(+) T cells and CD8(+) T cells in addition to antibodies. Such cell-mediated responses can be potentiated with adjuvants. However, very few adjuvants have been licensed for use in humans; thus there is an urgent need for the discovery of new non-toxic ad...
Numerous compounds are under evaluation as immunological adjuvants for improvement of vaccine performance. This review will briefly summarize some of the many diverse substances that are currently being utilized as vaccine adjuvants in preclinical and clinical studies.
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