Objective(s): Development of an oral sustained-controlled release vehicle which, slowly releases the drug and maintains an effective drug concentration for a long time is aimed.Materials and Methods: A biodegradable magnetic polymeric drug delivery vehicle, using superparamagnetic iron oxide nanoparticles encapsulating by polyvinylpyrrolidone-block-polyethylene glycol-block-poly methacrylic aci...

The attachment of polyethylene glycol (PEG) increases the circulation time of drug-containing nanoparticles; however, this also negatively affects cellular uptake. To overcome this problem, unique lipid polymer hybrid (LPH) nanoparticles were developed with a pH-responsive PEG layer that detached prior to cell uptake. Docetaxel (DTX) was incorporated into the lipid core of the nanoparticles, wh...

Architecture represents an underutilized yet promising control element in polymer design due to the challenging synthesis of compositionally varied branched copolymers. We report the one-pot synthesis of miktoarm branched polymers by ring-opening metathesis polymerization. In this work, we graft to and from telechelic poly(3-hexylthiophene), which is end-capped by oxime click chemistry, using v...

This work investigates polymeric coating of evaporated induced self-assembly (EISA) mesoprous silica nanoparticles for potential use in controlled drug release and therapeutics. As demonstrated here, lipid bilayer coatings can be easily replaced with different polymer analogs allowing for dynamic response to environmental stimuli. In addition to coupling commercially available diblock polymers ...

In recent years, stimuli responsive materials have gained significant attention in membrane separation processes due to their ability to change specific properties in response to small external stimuli, such as light, pH, temperature, ionic strength, pressure, magnetic field, antigen, chemical composition, and so on. In this review, we briefly report recent progresses in light-driven materials ...

A novel strategy was developed to synthesize uniform semi-interpenetrating polymer network (semi-IPN) microspheres by premix membrane emulsification combined with one-step polymerization. Synthesized poly(acrylic acid) (PAAc) polymer chains were added prior to the inner water phase, which contained N-isopropylacrylamide (NIPAM) monomer, N,N1-methylene bisacrylamide (MBA) cross-linker, and ammon...

One constraint of semiconducting polymer dots (Pdots), especially those with near-IR emission, is their low effective emitter ratio ( 1.5 mole percent), which limits their pH sensing performance. The other critical issue of existing Pdot-based pH sensors is their poor photostability. To address these issues, we developed a series of Pdots by dendronizing the squaraine-based pH responsive near-I...

The pH mediated intra-molecular association and inter-molecular aggregation of a range of amphiphilic poly(L-lysine iso-phthalamide) polymers have been investigated in aqueous solution over a range of pH values and concentrations. The desired functionality of these novel bioresponsive amphiphilic polymers was achieved by incorporating pendant hydrophilic carboxyl groups along the polymer backbo...

BACKGROUND Stimuli-responsive polymer materials are a new kind of intelligent materials based on the concept of bionics, which exhibits more significant changes in physicochemical properties upon triggered by tiny environment stimuli, hence providing a good carrier platform for antitumor drug delivery. RESULTS Dual stimuli-responsive Fe3O4 graft poly(acrylic acid)-block-poly(2-methacryloyloxy...

A thermo-, pH- and cyclodextrin- (CD) responsive poly(N-isopropylacrylamide) (PNIPAM), with a N,N-dimethylaminoazobenzene end group was synthesized. Using 3-mercaptopropionic acid as a chain transfer agent, PNIPAM with a well-defined COOH end group was obtained. The acid end group was transferred to the corresponding acid chloride and then functionalized with N,N-dimethyl[4-(4'-aminophenylazo)p...