BACKGROUND Mating decreases female receptivity and terminates sex pheromone production in moths. Although significant progress has been made in elucidating the mating-regulated inactivation of pheromone biosynthesis-activating neuropeptide (PBAN) secretion, little is known about the mating induced gene expression profiles in pheromone glands (PGs). In this study, the associated genes involved i...

BACKGROUND There is no consensus on the exact parameters that define the LH surge for natural cycle frozen-thawed embryo transfers (NC-FET). Accurately determining the LH surge would affect the timing, and subsequently the success rates, of embryo transfer. Therefore, the aim of this study was to delineate the optimal levels and relationship for luteinizing hormone (LH) and estradiol in an effo...

Prostaglandins (PGs) are lipid molecules that profoundly affect cellular processes including inflammation and immune response. Pathways contributing to PG output are highly regulated in antigen-presenting cells such as macrophages and monocytes, which produce large quantities of these molecules upon activation. In this report, we demonstrate aberrant constitutive expression of the normally indu...

Polychronization has been proposed as a possible way to investigate the notion of cell assemblies and to understand their role as memory supports for information coding. In a spiking neuron network, polychronous groups (PGs) are small subsets of neurons that can be activated in a chain reaction according to a specific timelocked pattern. PGs can be detected in a neural network with known connec...

Partizan Games (PGs) were invented by John H. Conway and are described in his book On Numbers and Games. We formalize PGs in Higher Order Logic extended with ZF axioms (HOLZF) using Isabelle, a mechanical proof assistant. We show that PGs can be defined as the unique fixpoint of a function that arises naturally from Conway’s original definition. While the construction of PGs in HOLZF relies hea...

Abstract It is well established that genetics, environment, and interplay between them play a crucial role in adult disease. We aimed to evaluate the of early life nutrition, interaction them, on optimal health. As part large international consortium (n ~ 154,000), we identified 60 SNPs associated with both birthweight Utilising Raine Study, developed polygenic score (BW-PGS) based examined rel...

OBJECTIVE Innovative strategies that facilitate the use of high quality practice guidelines (PG) are needed. Accordingly, repositories designed to simplify access to PGs have been proposed as a critical component of the network of linked interventions needed to drive increased PG implementation. The National Guideline Clearinghouse (NGC) is a free, international online repository. We investigat...

Despite extensive investigation, the biological mechanisms causing essential hypertension (EHT) remain unclear. To clarify the means by which hypotensive prostaglandins (Hypo-PGs, mainly PGE1 and PGE2) act in patients with EHT, the interaction between intravenously infused Hypo-PGs and pressor substances such as an adrenergic neurotransmitter, noradrenaline (NA) and angiotensin II (AII) was exa...

objective: the incidence of heart valve disease is increasing worldwide and the number of heart valve replacements is expected to increase in the future. by mimicking the main tissue structures and properties of heart valve, tissue engineering offers new options for the replacements. applying an appropriate scaffold in fabricating tissue-engineered heart valves (tehvs) is of importance since it...

Endo-polygalacturonases (PGs) are hydrolytic enzymes involved in the degradation of pectin, one of the major components of plant cell wall. While PGs from fungi, bacteria and plants have been extensively studied, PGs from insects are much less known, although they are likely to play an important role in insect-plant interactions. Presence of PGs has been reported for both piercing-sucking and c...