Introduction There is substantial interest in combining functional and anatomical imaging modalities into hybrid systems [1]. Efforts to combine PET and MRI must overcome the incompatibility of conventional PET detectors based on photomultiplier tubes (PMT) with magnetic fields. There are a number of approaches to PET and MRI modify PET detectors to make them compatible with conventional MRI [2...

Introduction: Tumor volume delineation is the most important step in the radiation treatment planning. In this study the impact of PET/CT data on the tumor delineation precision of non-small cell lung cancer (NSCLC) was investigated. Methods: PET/CT images of 20 patients with primary NSCLC were obtained and imported to the treatment planning system for im...

UNLABELLED This work addresses the clinical adoption of FDG-PET/CT for image-guided radiation therapy planning (RTP). As such, important technical and methodological aspects of PET/CT-based RTP are reviewed and practical recommendations are given for routine patient management and clinical studies. First, recent developments in PET/CT hardware that are relevant to RTP are reviewed in the contex...

BACKGROUND Quantitative measures of 11C-raclopride receptor binding can be used as a correlate of postsynaptic D2 receptor density in the striatum, allowing 11C-raclopride positron emission tomography (PET) to be used for the differentiation of Parkinson's disease from atypical parkinsonian syndromes. Comparison with reference values is recommended to establish a reliable diagnosis. A PET templ...

Andersson, C. 2018. PET/CT in oncology. Patient experience, image quality and the value of information. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1414. 80 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0197-6. The overall aim was to investigate patients’ experiences with a PET/CT examination, satisfaction with care provided in connection...

This study investigated the feasibility of quantitative accuracy and harmonized image quality in Zr-PET/CT multicentre studies. Methods: Five PET/CT scanners from 3 vendors were included. Zr activity was measured in a central dose calibrator before delivery.Local activity assays were based on volume as well as on the local dose calibrator. Accuracy and image noise were determined from a cross c...

UNLABELLED This study investigated the feasibility of quantitative accuracy and harmonized image quality in (89)Zr-PET/CT multicenter studies. METHODS Five PET/CT scanners from 3 vendors were included. (89)Zr activity was measured in a central dose calibrator before delivery. Local activity assays were based on volume as well as on the local dose calibrator. Accuracy and image noise were dete...

A whole-body PET/CT scan extending from the vertex of the head to the toes of the patient is not feasible on a number of commercially available PET/CT scanners due to a limitation in the extent of bed travel on these systems. In such cases, the PET scan has to be divided into two parts: one covering the upper body segment, while the other covering the lower body segment. The aim of this paper i...

A method for partial volume correction of positron emission tomography (PET) images is proposed. The method is based on combining information from PET and high resolution anatomical images. Two different algorithms fast wavelet transform and à trous were implemented in order to decompose the PET and high resolution images. Results obtained using several simulated images show a significant parti...

UNLABELLED CT-based attenuation correction is a widely used option in commercial PET/CT scanners. However, as a result of a nonsimultaneous acquisition and differences in temporal resolution between both modalities, a potential misregistration between the PET and CT, especially in the thorax and the upper abdomen, can be found. We observed a substantial number of apparent perfusion defects in s...