The therapeutic potential of gene therapy in cardiovascular disease such as post-angioplasty restenosis, myocardial ischaemia and severe peripheral artery disease ischemia are considered.

Methods: We conducted a comparative study of two groups of patients suffering from arterial insufficiency of the lower extremities, and the decision taken to amputate above the knee for both of them. A group of patients selected for a therapeutic peripheral intervention, and the effect of this intervention in improving the level of amputation studied and calculated statistically. The study cond...

Spontaneous coronary artery dissection (SCAD) is a very rare cause of peripheral artery thromboembolism. It is especially rare to show symptoms of acute limb ischemia without chest symptoms during a hospital visit. In this case, a rare case of SCAD led to left heart failure and caused left ventricle thrombi, which in turn caused peripheral thromboembolism.

traumatic injuries to the subclavian-axillary artery, although uncommon, are associated with high morbidity and mortality rates if not managed promptly. the emergence of endovascular techniques offers an alternative to the surgical management of these injuries. we herein present 4 cases of traumatic subclavian-axillary artery injury with limb ischemia successfully managed via the endovascular a...

Purpose: Mechanical closure devices for arterial hemostasis after angiography, such as the Perclose suture-mediated closure system, are designed to decrease time to ambulation and improve patient comfort. Although these devices are safe and efficacious, to date there has been little reported about use of the Perclose device in a cohort consisting exclusively of patients with lower extremity per...

Intermittent claudication (IC) from peripheral artery disease is typically managed with pharmacological interventions and lifestyle changes. However, despite societal guidelines, initial endovascular are being used more frequently increased complications, resulting in rapid progression to acute critical limb-threatening ischemia (ALI). This case concerns a patient who developed ALI following tr...

OBJECTIVES Experimental myocardial infarction triggers secretion of Stromal cell-derived factor1 and lead to increase in the expression of its receptor "CXCR4" on the surface of various cells. The aim of this study was to evaluate the expression pattern of CXCR4 in peripheral blood cells following time-course permanent and temporary ischemia in rats. MATERIALS AND METHODS Fourteen male Wistar...

Incontinentia pigmenti (IP) is a rare disease with multisystemic anomalies, which commonly presents just after birth. Here, we report a rare case of IP patient with vitreous hemorrhage in school-age children. Therefore, physicians have to be alert and evaluate IP patients at all ages. Regular ophthalmic follow-up is necessary, and fluorescein angiography should be performed if peripheral ischem...