conclusions these findings suggest that exposure to tc-99m could induce a radio-adaptive response against the exposure of tl-201. background low dose radiation will induce adaptation and following exposure to an adaptive dose, the cells are more resistance to following challenging doses. this phenomenon is known as radio-adaptive response. the aim of this study was to investigate the percentage...

background: ˝radioadaptive response˝ is well-documented phenomenon appeared in low dose ionizing radiation received in vitro and in vivo. occupational exposure has always been a great concern for radiation workers therefore this study was performed to study radioadaptive response in terms of residual dna double strand breaks as an endpoint in peripheral blood leukocytes of occupationally expose...

Present study reports analgesic activity of petroleum ether, chloroform, ethyl acetate and methanolic extracts of leaves and seeds of Trigonella foenum-graecum Linn. (Fabaceae) using hot plate method for evaluation of central analgesic activity and acetic acid induced writhing test for evaluation of peripheral analgesic activity in mice.   All the extracts of Trigonella foenum-graecum ...

FTY720 is a new and effective immunosuppressive agent, which produces peripheral blood lymphopenia through a lymphocyte homing effect. We investigated the relationship between the dose of FTY720 or blood concentration (pharmacokinetics, PK) and peripheral lymphopenia (pharmacodynamics, PD) in 23 kidney transplant recipients randomized to receive FTY720 (0.25-2.5 mg/day) or mofetil mycophenolate...

Introduction: A study was performed to evaluate radiation dose distribution and dose gradient around cylindrical applicators for high-dose-rate (HDR) brachytherapy systems with 192Ir, 60Co brachytherapy source applied for rectal and vaginal cancers treatments.   Materials and Methods: Two additional computed tomography (CT) based plans were generated using a ...

It is generally believed that estrogens exert their bone sparing effects directly on the cells within the bone compartment. The aim of the present study was to investigate if central mechanisms might be involved in the bone sparing effect of estrogens. The dose-response of central (i.c.v) 17beta-estradiol (E2) administration was compared with that of peripheral (s.c.) administration in ovariect...

background: lymphocyte-dicentric assay is the most generally accepted method for biological dosimetry of overexposed individuals. in this study, the frequency of unstable chromosome aberration in blood lymphocytes was used to estimate radiation dose received by individuals. evaluation of dose using a calibration curve produced elsewhere may have a significant uncertainty therefore, experiments ...

In vivo endotoxin infusion produces neutrophil-mediated acute lung injury and increases superoxide anion release from phorbol myristate acetate (PMA) -stimulated blood neutrophils collected 18-24 hours after the infusion. Because the turnover time of circulating blood neutrophils is only 6-8 hours, it was hypothesized that the prolonged increase in superoxide anion release from peripheral blood...

The rhizome of Canna indica L. (family: Cannaceae) was extracted in methanol and two doses- 200 400 mg/kg body weight the extract were employed to reveal central peripheral analgesic, hypoglycemic antidiarrheal properties vivo. According tail immersion technique, both doses significantly rose time latent response for 90 minutes compared control mice group assessing analgesia. Acetic acid-induce...

Out-of-field dose depends on multiple factors, making peripheral dosimetry com-plex. Only a few dosimeters have the required features for measuring peripheral dose. Plastic scintillator dosimeters (PSDs) offer numerous dosimetric advantages as required for out-of-field dosimetry. The purpose of this study is to determine the potential of using PSD as a surface peripheral dosimeter. Measurements...