In this review, we highlight, summarize, and evaluate the use of various transition metals in chemical synthesis peptides proteins with emphasis on recent developments exciting research area.

The destabilization of UHT milk during its shelf life can be promoted by the residual proteolytic activity attributed to protease AprX from Pseudomonas. To better understand hydrolysis patterns AprX, and evaluate feasibility using low-temperature inactivation (LTI) for release peptides through on proteins was examined an LC-MS/MS-based peptidomic analysis. Milk samples were either directly incu...

Our research group has been studying the design of intracellular delivery peptides based on cationic lytic peptides. By placing negatively charged amino acids potentially hydrophobic faces peptides, membrane activity is attenuated cell surface, whereas it recovers in endosomes, enabling cytosolic proteins including antibodies. These generally contain multiple lysines, facilitating surface inter...

Introduction: Scorpion venoms contain a variety of peptides, toxic to mammals، insects and crustaceans and are the main factors in scorpion venom toxicity (their amount being 1-3% of total venom). Most of the scorpion toxins have been isolated from the venoms of scorpions in the Buthidae family. The scorpion Buthotus Schach of this family is widely found in the western regions of Iran, but no p...

Liquid-liquid phase separation (LLPS) of proteins mediates the assembly biomolecular condensates involved in physiological and pathological processes. Identifying minimalistic building blocks sequence determinant protein is an urgent need but remains challenging partially due to lack methodologies characterize behavior. Here, we demonstrate computational tools efficiently quantify microscopic f...

ABSTRACT Lena Ho studied biochemistry at the University of Wisconsin–Madison, USA, funded by a scholarship from Singapore Economic Development Board. then joined lab Gerald Crabtree Stanford for her PhD, where she investigated function and mechanism chromatin remodelling proteins in epigenetic regulation embryonic, haematopoietic cancer stem cells. She moved back to postdoc Bruno Reversade's In...

introduction: scorpion venoms contain a variety of peptides, toxic to mammals، insects and crustaceans and are the main factors in scorpion venom toxicity (their amount being 1-3% of total venom). most of the scorpion toxins have been isolated from the venoms of scorpions in the buthidae family. the scorpion buthotus schach of this family is widely found in the western regions of iran, but no p...

Peptides and proteins play an essential role in biological systems the human body. Deficiency or dysfunction of peptides such as insulin can lead to various illnesses. The therapeutic use some illnesses diabetes, cardiovascular disease, autoimmunity, cancer, among others, is highly considered. have large molecular structures are generally hydrophilic, maintaining their spatial composition terti...