b ackground: brevinin-2r, as 25 amino acids peptide of the skin of r ana ridibunda frog, possesses potent antimicrobial and low hemolytic activity. it has an n-terminal hydrophilic region and a c-terminal loop that is delineated by an intra-disulfide bridge. in our study, brevinin-2r and its diastereomer as well  as its  cyclic  analogue  were  synthesized  and  characterized  in  order  to inv...

Background: RADA16I represents one of promising hydrogel forming peptides. Several implementations of RADA16I hydrogels have proven successful in the field of regenerative medicine and tissue engineering. However, RADA16I peptides used in various studies utilize synthetic peptides and so far, only two research articles have been published on RADA16I peptide recombinant producti...

The zinc metalloprotease, neprilysin (NEP), plays a role in the metabolism of cardiovascular, inflammatory and neuropeptides, including mitogenic peptides such as bombesin. In the cardiovascular system, NEP has a primary role in the inactivation of natriuretic peptides but also contributes to local metabolism of angiotensin, endothelins and bradykinin. Hence NEP is seen as a potential therapeut...

     Furin is a Ca 2+ <span style="color: #231f20; font-family: Times New...

Computer simulation has been used to identify peptides that mimic the natural target of SARS-CoV-2 coronavirus spike (S) protein, angiotensin converting enzyme type 2 (ACE2) cell receptor. Based on structure complex protein S receptor-binding domain (RBD) and ACE2, design chimeric molecules consisting two 22-23-mer linked each other by disulfide bonds was carried out. The molecule X1 a dimer, i...

Abstract Synthetic peptide pools are used in experimental and clinical immunology, for example, cancer immunotherapy. The analytical characterization is challenging due to the similarity of peptides, usually only a pre-characterization single peptides performed. However, regular quality control mix would be highly desirable. Therefore, high performance liquid chromatography-high resolution mass...

In the present study, we tested effect of small-molecular-weight redox molecules on collagen-induced platelet aggregation. We used N-acetylcysteine amide (AD4/NACA), form (NAC), a thiol antioxidant with improved lipophilicity and bioavailability compared to NAC, thioredoxin-mimetic (TXM) peptides, TXM-CB3, TXM-CB13, TXM-CB30. All compounds significantly inhibited aggregation induced by collagen...

Lin et al. examined the effects of lipid chains attached to N-terminal antimicrobial peptides, a type membrane-active on their membrane activity and bioactivity. The impact lipidation varied depending original peptides' hydrophobicity. By altering peptide conformations affecting self-aggregation behaviours, changed peptide-biomembrane interaction, ultimately bioactivity (e329).