The way of the development of the cellulose-bound peptide arrays leads via the synthesis of oligonucleotides on cellulose pieces (Frank et al., 1983) and multiple peptide synthesis on cellulose paper discs in columns (Frank and Döring, 1988). Probably inspired by the addressability of the multipin method (Geysen et al., 1984), Ronald Frank and co-workers developed SPOT synthesis and first prese...

INTRODUCTION............ 449 PROPERTIES OF PEPTIDE ANTIBIOTICS 449 FORMATION OF ANTIBIOTICS IN RELATION TO GROWTH ...... ............ 450 CELL-FREE SYNTHESIS OF PEPTIDE ANTIBIOTICS ...... .................. 451 ENZYMATIC SYNTHESIS OF GRAMICIDIN S ........ ......................... 451 ENZYMATIC FORMATION OF TYROCIDINE ........ ......................... 453 LINEAR GRAMICIDINS ......................

introduction: it has been shown that some primary human tumors and their metastases, including prostate and breast tumors, over-express gastrin-releasing peptide (grp) receptors. bombesin is a neuropeptide with a high affinity for these grp receptors. the purpose of this study was to prepare and evaluate the characteristics of a new freeze-dried kit, [6-hydrazinopyridine-3-carboxylic acid (hyni...

Guaranteed QoS Synthesis (GQS) is a distributed measurement-based admission control scheme. It is designed as a simple and scalable approach to providing strong service guarantees using bulk packet congestion marking across a core network region. We describe the operation and performance of GQS, with particular reference to its use for fair resource-sharing between guaranteed traffic and a rate...

milk proteins provide a natural source of bioactive peptides with potential health benefits and applications in the food industry. the release of these peptides from milk proteins is achieved either by hydrolysis using digestive proteases or by lactic acid bacteria fermentation. peptides, particularly those derived from milk proteins, can exert a wide range of nutritional, functional and biolog...

During the past few years, synthetic DNA, used as a primer in DNA polymerization, in site-directed mutagenesis or as a probe in gene selection, has assumed a central role in recombinant DNA technology (1). This was made possible by the development of methods for efficient solid phase chemical synthesis. Deoxyribonucleotides are ideally suited to solid-phase synthesis since their relative chemic...

18.1 The Challenge of Delivery of Oligonucleotide Analogs and siRNA into Cells in Culture and In Vivo ............................................ 313 18.2 Chemical Synthesis of Peptide–Oligonucleotide Conjugates .............. 314 18.2.1 Synthesis of CPP Conjugates to Phosphate-Containing Oligonucleotides ...................................................................... 315 18.2.2 Synthes...

Peptide bond formation from aminoacyl transfer RNA and ammonium chloride-washed ribosomes can occur extensively in the absence of supernatant enzymes. More than 50% of the W-phenylalanine-tRNA can be converted into oligophenylalaninetRNA. Although diphenylalanine is the major product, the oligophenylalanine formed consisted of 73, 16, and 9.7% of di-, tri-, and tetraphenylalanine, respectively....

Peptide bond formation from aminoacyl transfer RNA and ammonium chloride-washed ribosomes can occur extensively in the absence of supernatant enzymes. More than 50% of the W-phenylalanine-tRNA can be converted into oligophenylalaninetRNA. Although diphenylalanine is the major product, the oligophenylalanine formed consisted of 73, 16, and 9.7% of di-, tri-, and tetraphenylalanine, respectively....