BACKGROUND Historically, US federal policy has not supported harm reduction interventions, such as safe injection facilities (SIFs) and needle and syringe programs (NSPs), which can reduce the burden associated with injection drug use. Given recent increases in abuse of both legal and illegal opioids, there has been a renewed debate about effective ways to address this problem. The current stud...

OBJECTIVE Although our understanding of viral transmission among people who inject drugs (PWID) has improved, we still know little about when and how many times each injector transmits HIV throughout the duration of infection. We describe HIV dynamics in PWID to evaluate which preventive strategies can be efficient. DESIGN Due to the notably scarce interventions, HIV-1 spread explosively in R...

BACKGROUND AND AIMS People who inject drugs (PWID) are historically viewed as having "difficult to treat" hepatitis C disease, with perceived inferior treatment adherence and outcomes, and concerns regarding reinfection risk. We evaluated for differences in treatment adherence and response to Peginterferon-alfa-2a/Ribavirin (Peg-IFNα/RBV) in a large urban cohort with and without a history of re...

Commentary Asia and the Pacific region is one of the world’s most vibrant places in terms of economic growth and social advancement. It captures many superlatives: the planet’s highest proportion of young people, the largest megacities in the world and Asia wins the crown of "global growth leader" again and again. However, despite the dynamism, some citizens are falling through the cracks. This...

Abstract Background The Kentucky Income Reinvestment Program (KIRP) provides comprehensive early intervention services targeting those at the highest risk for HIV infection. objective of this study was to evaluate prevalence Hepatitis C Antibodies (HCV Ab) in people infections Kentucky. Methods A cross-sectional conducted using KIRP Outreach database, including data from January 2021 March 2022...

BACKGROUND Sharing of equipment used for injecting drug use (IDU) is a substantial cause of disease burden and a contributor to blood-borne virus transmission. We did a global multistage systematic review to identify the prevalence of IDU among people aged 15-64 years; sociodemographic characteristics of and risk factors for people who inject drugs (PWID); and the prevalence of HIV, hepatitis C...

BACKGROUND & AIMS Chronic hepatitis C virus (HCV) infection can significantly reduce health-related quality of life (QoL), but it is not clear if reduction is associated with the infection or with being aware of one's infection status. Understanding the impact of a HCV diagnosis on QoL is essential to inform decision-making regarding screening/testing and treatment. METHODS Using a cross-sect...

Concerns remain regarding the heterogeneity in overlapping human immunodeficiency virus (HIV) risk behaviors among sex workers (SWs) in Pakistan; specifically, the degree to which SWs interact with people who inject drugs (PWID) through sex and/or needle sharing.Following an in-depth mapping performed in 2011 to determine the size and distribution of key populations at highest risk of HIV acqui...

Background: Few studies suggest that social network factors, including size of sexual network may associate with drug-related and sexual high-risk behaviors. The objective of this study is to investigate injecting and sexual networks and sociodemographic factors that might be associated with dual HIV risk (DHR) among people who inject drug (PWID).Methods: The data from a cross-sectional study o...