نتایج جستجو برای: pentylenetetrazole

تعداد نتایج: 1252  

2012
Rafael Rodríguez Thomas Sikora Rubén Heras Evangelio

2009
Abhay Sharma Farhan Mohammad Priyanka Singh

A male Drosophila model of locomotor deficit induced by chronic pentylenetetrazole (PTZ), a proconvulsant used to model epileptogenesis in rodents, has recently been described. Antiepileptic drugs (AEDs) ameliorate development of this behavioral abnormality. Time-series of microarray profiling of heads of male flies treated with PTZ has shown epileptogenesis-like transcriptomic perturbation in ...

Journal: :Epilepsy & Behavior 2015
Clarissa F. Cavarsan Alisson Matsuo Miriam M. Blanco Luiz E. Mello

OBJECTIVE Homer1a is a protein that regulates metabotropic glutamate receptors involved in neural plasticity processes. Recently, we demonstrated that Homer1a mRNA is enhanced after pilocarpine-induced status epilepticus. Here, we investigated whether a single acute seizure triggered by means of pentylenetetrazole (PTZ) injection or maximal electroshock (MES) stimulation (2 different seizure mo...

Journal: :Phytotherapy research : PTR 2006
John A O Ojewole George J Amabeoku

Various morphological parts of Persea americana Mill (Lauraceae) (avocado) are widely used in African traditional medicines for the treatment, management and/or control of a variety of human ailments, including childhood convulsions and epilepsy. This study examined the anticonvulsant effect of the plant's leaf aqueous extract (PAE, 50-800 mg/kg i.p.) against pentylenetetrazole (PTZ)-, picrotox...

2017
Ali Gharibi Loron Soroush Sardari Jamshid Narenjkar Mohammad Sayyah

BACKGROUND Resistance to antiepileptic drugs and the intolerability in 20-30% of the patients raises demand for developing new drugs with improved efficacy and safety. Acceptable anticonvulsant activity, good tolerability, and inexpensiveness of docosahexaenoic acid (DHA) make it as a good candidate for designing and development of the new anticonvulsant medications. METHODS Ten DHA-based mol...

Journal: :Journal of ethnopharmacology 2008
Muhammad Nisar Inamullah Khan Shabana Usman Simjee Anwarul Hasan Gilani Obaidullah Humera Perveen

Taxus wallichiana Zucc. (Himalayan Yew) is often used in northern areas of Pakistan for the treatment of pyrexia, acute pains and epilepsy. We have investigated certain pharmacological activities of the methanol leaf extract against convulsion, nociception and pyrexia induced in rodents. The aim was to justify and explore its folk uses in these pathological conditions, on scientific basis. The ...

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