Background: Despite the efforts to enhance hygiene education and personal hygiene and use of antibiotics and vaccination, infectious diseases remain the second cause of mortality worldwide. Vaccination is one of the greatest medical achievements in the prevention of mortality and morbidity, which has decreased treatment costs. This study aimed to compare the complications caused by pentavalent ...

Cutaneous leishmaniasis (CL) has been recognized as a major public health problem in several countries. It is highly endemic in the north and east Mediterranean regions in the Syrian Arab Republic with more than 75.9% of all CL cases recorded from these regions. Pentavalent antimonials have been considered as standard treatment for leishmaniasis. Use of pentavalent antimonials to treat leishman...

The electrical resistivity, magnetic susceptibility, and heat capacity of sintered samples Ca2Ir2O7, in which pentavalent Ir atoms with 5d4 electron configuration form a pyrochlore structure, have been studied. obtained experimental data strongly suggest that Ca2Ir2O7 is metallic below room temperature exhibits no electronic or phase transitions above 0.12 K.

UNLABELLED Cutaneous leishma iasis (CL) is zoonosis with a spectrum of cutaneous manifestations caused by protozoan parasites of thegenus Leishmania.Manifestation varies according to the parasite virulence and the host immune response. Pentavalent antimonials (sodium stibogluconate and meglumine antimoniate) have been used as a first-line therapy for the last 70 years around the world.We report...

Protein toxins produced by bacteria are the cause of many life-threatening diarrheal diseases. Many of these toxins, including cholera toxin (CT), enter the cell by first binding to glycolipids in the cell membrane. Inhibiting these multivalent protein/carbohydrate interactions would prevent the toxin from entering cells and causing diarrhea. Here we demonstrate that the site-specific modificat...

Pentavalent organo-vanadates have been used extensively to mimic the transition state of phosphoryl group transfer reactions. Here, decavanadate (V(10)O(28)6-) is shown to be an inhibitor of catalysis by bovine pancreatic ribonuclease A (RNase A). Isothermal titration calorimetry shows that the Kd for the RNase A decavanadate complex is 1.4 microM. This value is consistent with kinetic measurem...